The interest in economic evaluation of alternative strategies for haemophilia treatment has increased through the years. Few studies have actually been undertaken, however, and most of them have been simple cost-minimization or cost-effectiveness analyses. From the perspective of the binational project 'Treatment strategies for severe haemophilia-prophylaxis vs. on-demand', the present paper di...

1 Moore CP, Sarti DA, Louie JS. Ultrasonographic demonstration of popliteal cysts in rheumatoid arthritis. Arthritis Rheum 1975; 18: 577–80. 2 Fritschy D, Fasel J, Imbert JC, Bianchi S, Verdonk R, Wirth CJ. The popliteal cyst. Knee Surg Sports Traumatol Arthrosc 2006; 14: 623–8. 3 Rodrigue V, Shaughnessy WJ, Schmidt KA, Slaby JA, Gilchrist GS, Pruthi RK. Haemorrhage into a popliteal cyst: an un...

The current treatment of haemophilia with coagulation protein replacement therapy is both effective and safe. Nevertheless, this therapy requires frequent, repeated intravenous infusions and approximately 25% of treated haemophilia A patients develop antibodies to the replacement protein. Furthermore, the cost and limited availability of current concentrates has restricted access to therapy to ...

The unintentional contamination of haemophilia patients with HIV in the early 1980s raised serious questions about the safety of blood product supplies worldwide. The events initiated a cascade of consequences for both infected patients and the national health systems of many countries, including the Islamic Republic of Iran. Lawsuits have been filed in the courts mostly in developed countries,...

Haemophilia is a rare and congenital bleeding disorder caused by a genetic defect, resulting in a lack of or insufficient coagulation factors VIII or IX in the body. In affected individuals, this causes an inability to clot blood, leading to bleeds in the joints, muscles and soft tissues. If left untreated, this can lead to disability and sometimes death. It is widely agreed that the optimal st...

A 69-year-old man was admitted to the hospital with persistent hiccups. Computed tomography and magnetic resonance imaging of the brain were performed and revealed a glioblastoma multiforme localised in the right temporal lobe. After resection, the hiccups disappeared, suggesting that temporal areas are involved in control mechanisms of hiccups. A month later, the patient was readmitted because...

According to classical genetics, a recessive sex-linked or X-linked gene manifests its existence phenotypically only in the absence of its normal allele, that is, in the homozygous state or in the absence of a second X chromosome carrying the normal allele. The latter requirement is met, for instance, in males who have haemophilia as a sex-linked trait: they have only one X chromosome in their ...

UNLABELLED Clot waveform analysis extends the interpretation of aPTT measurement curves. The curve is mathematically processed to obtain information about fibrin formation kinetics including semiquantitative determination of thrombin, prothrombinase and tenase activity. PATIENTS, METHOD In this study the feasibility of clot waveform analysis for monitoring of haemophilia A was investigated us...

1Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal 2 ICVS/3B’s – PT Government Associate Laboratory, Braga/Guimarães, Portugal 3School of Psychology, University of Minho, Braga, Portugal 4Faculty of Psychology and Education Sciences, University of Porto, Porto, Portugal 5Portuguese Haemophilia Association, Lisbon, Portugal 6European Hae...

Haemophilia is a congenital coagulation defect brought about by the deficiency or lack of coagulation factor IX. The prevalence of coronary artery disease and acute coronary syndrome (ACS) is lower among haemophiliacs than in the normal population. However, with the administration of factor concentrate, average life expectancy can now extend to as long as 70 years in patients with haemophilia, ...