نتایج جستجو برای: h7n9 subtype
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UNLABELLED The emergence of avian H7N9 viruses in humans in China has renewed concerns about influenza pandemics emerging from Asia. Vaccines are still the best countermeasure against emerging influenza virus infections, but the process from the identification of vaccine seed strains to the distribution of the final product can take several months. In the case of the 2009 H1N1 pandemic, a vacci...
TO THE EDITOR—H7N9 is a novel avian virus recently first reported from Shanghai in China. Very recently an isolate from Taiwan was also reported [1]. H7N9 is able to infect humans and has caused many fatal cases [2, 3]. Determining the origin and evolution of these disease-causing viruses is important for surveillance and prevention of the influenza epidemics. With more and more reported pathog...
Novel avian influenza A(H7N9) virus was isolated in fatal patients in Yangtze River Delta of China in March 2013. We aimed to screen the virus in febrile patients in a tertiary hospital in an area with confirmed cases. Throat-swab specimens collected from consecutive patients with fever (≥38°C) and flu-like symptoms from April 15 to April 25, 2013 were subjected to detect novel avian influenza ...
Secondary bacterial lung infection (SBLI) is a serious complication in patients with H7N9 virus infection, and increases disease severity. The oropharyngeal (OP) microbiome helps prevent colonisation of respiratory pathogens. We aimed to investigate the OP microbiome of H7N9 patients with/without secondary bacterial pneumonia using 16S rRNA gene sequencing. OP swab samples were collected from 5...
OBJECTIVES This study aims to describe the spatial and temporal characteristics of human infections with H7N9 virus in China using data from February 2013 to March 2014 from the websites of every province's Population and Family Planning Commission. METHODS A human infection with H7N9 virus dataset was summarized by county to analyze its spatial clustering, and by date of illness onset to ana...
The emergence and seasonal persistence of pathogenic H7N9 influenza viruses in China have raised concerns about the pandemic potential of this strain, which, if realized, would have a substantial effect on global health and economies. H7N9 viruses are able to bind to human sialic acid receptors and are also able to develop resistance to neuraminidase inhibitors without a loss in fitness. It is ...
BACKGROUND Since the identification in early 2013 of severe disease caused by influenza A(H7N9) virus infection, there have been few attempts to characterize the full severity profile of human infections. Our objective was to estimate the number and severity of H7N9 infections in Guangzhou, using a serological study. METHODS We collected residual sera from patients of all ages admitted to a h...
A novel avian influenza A(H7N9) virus causing human infection emerged in February 2013 in China. To elucidate the mechanism of interspecies transmission, we compared the signature amino acids of avian influenza A(H7N9) viruses from human and non-human hosts and analysed the reassortants of 146 influenza A(H7N9) viruses with full genome sequences. We propose a genetic tuning procedure with conti...
Avian-origin influenza A (H7N9) viruses emerged as human pathogens in China in early 2013 and have killed >100 persons. Influenza vaccines are mainly manufactured using egg-based technology which could not meet the surging demand during influenza pandemics. In this study, we evaluated cell-based influenza H7N9 vaccines in ferrets. An egg-derived influenza H7N9 reassortant vaccine virus was adap...
Low immunogenicity predicted for emerging avian-origin H7N9 Implication for influenza vaccine design
950 Human Vaccines & Immunotherapeutics Volume 9 Issue 5 *Correspondence to: Anne S. De Groot; Email: [email protected] Submitted: 04/03/13; Revised: 05/03/13; Accepted: 05/04/13 http://dx.doi.org/10.4161/hv.24939 a new avian-origin influenza virus emerged near shanghai in February 2013, and by the beginning of May it had caused over 130 human infections and 36 deaths. Human-to-human transmissi...
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