WHAT KIND OF WORLD is it where some postganglionic sympathetic nerves secrete acetylcholine and where norepinephrine in conjunction with neuropeptide Y facilitates a key vasodilator response? It is the upside-down world of the human skin that possesses perhaps the most complex regional circulation in nature. Skin responds to environmental stimuli in ways that might be described as beautiful and...

Evidence has been gathering from several laboratories that protons in proton-pumping membranes move along or within the bilayer rather than exchange with the bulk phase. These experiments are typically conducted on the natural membrane in vivo or in vitro or on fragments of natural membrane. Anionic lipids are present in all proton-pumping membranes. Model studies on the protonation state of th...

Anaplastic lymphoma kinase (ALK) rearrangements have been identified in 3–5 % non-small cell lung cancer (NSCLC) patients, with echinoderm microtubule associated protein like 4 gene (EML4) being the most common fusion partner. Huntingtin-interacting 1 (HIP1) has recently as a novel partner fused to ALK NSCLC three different HIP1-ALK variants reported (H28:A20), (H21:A20) and (H30:A20) date [1Fa...

We propose a two sublattice model with a doubly periodic on-site potential to describe the proton transport in hydrogen-bonded quasi-one-dimensional networks. The discrete system is reduced to a continuum double Sine-Gordon equation for the protonic part plus a simple differential equation for the heavy ion part. Its two-component kink solitons correspond to the ionic and B j e m defects. The c...

THE CARDIOTONIC EFFECTS of digitalis have been exploited in clinical practice for many years. However, while the existence of endogenous digitalis-like substances (also called cardiotonic steroids) has been accepted for some time, their exact chemical nature has been only recently demonstrated (1). Specifically, both cardenolide (e.g., ouabain) and bufodienelide (e.g., marinobufagenin) have bee...

The effect of host plant cultivar on H2 evolution by root nodules was examined in symbioses between Pisum sativum L. and selected strains of Rhizobium leguminosarum. Hydrogen evolution from root nodules containing Rhizobium represents the sum of H2 produced by the nitrogenase enzyme complex and H2 oxidized by any uptake hydrogenase present in those bacterial cells. Relative efficiency (RE) calc...

The relative efficlency (RE) ofN2 fxation (RE -1 H2 evolved In airl /[acetylene reducedi) was Investigated In a Rhizobiwm strain lackng uptake hy se actMity (Hup-). Vadation in RE of such strains presmably reflects changes In the electron allocation coefficient of nitrogenase. By artificially exteming the normal dark period of 24day-old Pism sativwn L cv 'Alaska' inoculated with the HupR. kgwni...

Although most physicians are comfortable managing the limited anticoagulant effect of aspirin, recent administration potent P2Y12 receptor inhibitors in patients undergoing cardiac surgery remains a dilemma. Guidelines recommend discontinuation 5- to- 7 days before to reduce risk postoperative hemorrhage. Such strategy might not be feasible urgent surgery, due ongoing myocardial ischemia or at ...

Central MessageSuspicion of myocardial ischemia right after cardiac surgery requires prompt clinical evaluation and transfer to the catheterization laboratory or operating room, if deemed necessary.See Commentaries on pages 1202 1203.Feature Editor's Introduction—Diagnosing infarction following can be challenging. Hospitals have different activation protocols when is suspected, which ultimately...