نتایج جستجو برای: h1299 cells

تعداد نتایج: 1383604  

Journal: :Cancer research 2001
W G Zhu R R Lakshmanan M D Beal G A Otterson

Histone acetylation has long been associated with transcriptional activation, whereas conversely, deacetylation of histones is associated with gene silencing and transcriptional repression. Here we report that inhibitors of histone deacetylase (HDAC), depsipeptide and trichostatin A, induce apoptotic cell death in human lung cancer cells as demonstrated by DNA flow cytometry and Western immunob...

Journal: :Molecular Medicine Reports 2021

Long non?coding RNAs (lncRNAs) are involved in the occurrence and progression of numerous types cancer. The aim present study was to evaluate effect lncRNA maternally expressed gene 3 (MEG3) on migration invasion non?small cell lung cancer (NSCLC) H1299 PC9 cells. Reverse transcription?quantitative (RT?q)PCR analysis showed that MEG3 downregulated NSCLC Additionally, bioinformatics indicated sp...

2013
Zhigang Li Lixue Dong Eric Dean Li V. Yang

Acidosis is a biochemical hallmark of the tumor microenvironment. Here, we report that acute acidosis decreases c-Myc oncogene expression in U937 human lymphoma cells. The level of c-Myc transcripts, but not mRNA or protein stability, contributes to c-Myc protein reduction under acidosis. The pH-sensing receptor TDAG8 (GPR65) is involved in acidosis-induced c-Myc downregulation. TDAG8 is expres...

2014
Chen Zhang Yuanzhuo Chen Mingsong Wang Xianzhen Chen Yongxin Li E Song Xiaoqing Liu Sekwon Kim Hu Peng

BACKGROUND PPM1D (protein phosphatase, Mg2+/Mn2+ dependent, 1D) has been reported to be involved in multiple human tumors. This study was designed to investigate the functional role of PPM1D in lung cancer cells. METHODS Expression levels of PPM1D were analyzed in A549 and H1299 cells by real-time PCR and Western blotting. Lentivirus-mediated short hairpin RNA (shRNA) was used to knock down P...

2007
Eun Jung Choi Young Mi Whang Seok Jin Kim Hyun Jin Kim Yeul Hong Kim

The growth inhibitory effects of four retinoic acid (RA) derivatives, 9-cis RA, 13-cis RA, N-(4-hydroxyphenyl) retinamide (4-HPR), and all-trans retinoic acid (ATRA) were compared. In addition, the effects of various combinations of these four agents were examined on non-small cell lung carcinoma (NSCLC) cell-lines, and on the expressions of retinoic acid receptors (RARs) and retinoid X recepto...

Journal: :Molecules 2017
Yunping Tang Fangmiao Yu Guomei Zhang Zuisu Yang Fangfang Huang Guofang Ding

Nereis active protease (NAP) is a novel fibrinolytic active serine protease from the polychaete Nereis virens. In this study, NAP was purified from Nereis virens and the effects of NAP on human lung cancer cells were investigated. Our results indicated that NAP inhibited the proliferation and induced apoptosis of H1299 cells in a time- and dose-dependent manner. The loss of mitochondrial membra...

Journal: :Molecules 2015
Jih-Tung Pai Chia-Yun Hsu Kuo-Tai Hua Sheng-Yung Yu Chung-Yang Huang Chia-Nan Chen Chiung-Ho Liao Meng-Shih Weng

Disrupting lung tumor growth via histone deacetylases (HDACs) inhibition is a strategy for cancer therapy or prevention. Targeting HDAC6 may disturb the maturation of heat shock protein 90 (Hsp90) mediated cell cycle regulation. In this study, we demonstrated the effects of semisynthesized NBM-T-BBX-OS01 (TBBX) from osthole on HDAC6-mediated growth arrest in lung cancer cells. The results exhib...

Journal: :Cancer Cell International 2021

Abstract Background Autophagy is a double-edged sword during the initiation and progression of multiple tumors. The Hippo pathway effector YAP has been proved to be involved in autophagy processes. present study aimed investigate how regulates cell proliferation via lung adenocarcinomas (LUAD). Methods Data LUAD chip GSE43458 was obtained from Gene Expression Omnibus (GEO). RT-qPCR Western blot...

2017
Hengli Dou Zhaohua Yan Meng Zhang Xiaoxin Xu

Non-small-cell lung cancer (NSCLC) is the major subtype of lung cancer, which is the most common cause of cancer-related mortality in the world. It is a complex disease involving multiple genetic alterations. As a cytokine belonging to the Tumor Necrosis Factor-α (TNF- α) family, the - a proliferation-inducing ligand (APRIL) expression and its signaling have been studied in many human solid tum...

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