نتایج جستجو برای: gvhd
تعداد نتایج: 4940 فیلتر نتایج به سال:
Acute graft-versus-host disease (GVHD) afflicts as much as 80% of all patients who receive an unrelated donor hematopoietic cell transplant (HCT) for the treatment of blood disorders, even with optimal donor HLA matching and use of prophylactic immunosuppressive agents. Of patients who develop acute GVHD, many are at risk for chronic GVHD and bear the burden of considerable morbidity and lowere...
Graft-versus-host disease (GVHD) remains a major limitation of allogeneic hematopoietic cell transplantation (allo-HCT). Despite major advances in the understanding of GVHD pathogenesis, standard GVHD prophylaxis regimens continue to be based on the combination of a calcineurin inhibitor with an antimetabolite, while first line treatments still rely on high-dose corticosteroids. Further, no sec...
This consensus document provides an update for pathologists and clinicians about the interpretation of biopsy results and use of this information in the management of hematopoietic cell transplantation patients. Optimal sampling and tissue preparation are discussed. Minimal criteria for the diagnosis of graft-versus-host disease (GVHD) are proposed, together with specific requirements for the d...
BackgroundVulvovaginal graft-versus-host disease (GVHD) is an underdiagnosed and poorly recognized complication of HSCT1,2. We aim to present hysteroscopic management cervicovaginal dense adhesions developed as a long-term sequelae vulvovaginal GVHD in 16-years-old girl who has Diamond-Blackfan Anemia. The institutional review board approval was obtained.CaseA presented with pelvic pain for las...
Background: Cyclosporine (CSA) is required as a prophylaxis of graft-versus-host disease (GVHD) following allogeneic haematopoietic stem cell transplant (HSCT). However, subtherapeutic CSA concentration will increase the incidence acute GVHD which one major concerns. Objective: This study aims to identify patients who achieved therapeutic initial level with standard intravenous dose 1.5 mg/kg B...
Patients who receive stem cell transplantation (SCT) can develop cutaneous eruptions with systemic involvement such as graft versus host disease (GVHD), drug hypersensitivity syndrome (DIHS), or viral exanthema. These conditions often have overlapping clinical and laboratory presentations may be associated risk factors reactivation medications. In this study, we evaluated the incidence, present...
introduction: in 1989, the first successful umbilical cord blood transplantations (ucbts) was reported in a boy with fanconi's anemia, using umbilical cord (ucb) of his hla matched sister. cord blood transplantation is a good substitute for bone marrow or peripheral blood transplantation especially for children and small body size adults. methods: between 1998 and 2007 ,14 children(10 boys and ...
BACKGROUND In this study we examined the in vivo and in vitro effects and mechanisms of action of curcumin on the development of acute graft-versus-host disease (GVHD) using a murine model. METHODOLOGY/PRINCIPAL FINDINGS Mixed lymphocyte reactions were used to determine the in vitro effects of curcumin. Treatment with curcumin attenuated alloreactive T cell proliferation and inhibited the pro...
BACKGROUND Allogeneic bone marrow transplantation (allo-BMT) is a potentially curative therapy for a variety of hematologic diseases, but benefits, including graft-versus-tumor (GVT) activity are limited by graft-versus-host-disease (GVHD). Carcinoembryonic antigen related cell adhesion molecule 1 (Ceacam1) is a transmembrane glycoprotein found on epithelium, T cells, and many tumors. It regula...
Graft-versus-host disease (GVHD) is a major cause of morbidity and mortality of allogeneic stem cell transplantation. Strategies to control GVHD while maintaining graft versus leukemia (GVL) include herpes simplex virus thymidine kinase (HSV-tk) gene transduction of donor T cells followed by treatment with ganciclovir (GCV). Alternatively, GVHD and GVL may be mediated by distinct processes. In ...
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