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Submit Manuscript | http://medcraveonline.com classes of pyrimidines. The pharmaceutical importance of these compounds lies on the fact that they can be effectively used as analgesics, anti-inflammatory, anticonvulsant, insecticidal, herbicidal, antitubercular, anticancer and antidiabetic agents [4-6]. Also, the pyrimidine and aminopyrimidine structures are frequently-occurring motifs in commer...

Using the marine natural product ptilocaulin as a starting point, supramolecular behavior of N,N′-bridged guanidinium nitrates in crystalline state was investigated. For this purpose, various guanidines were synthesized (typically by condensation 1,2- or 1,3-diamine with cyanogen bromide) and subsequently converted into their nitrate salts nitric acid. The crystal structures 28 samples determin...

Compounds with excellent receptor engagement displaying ?2-AR antagonist activity are useful not only for therapeutic purposes (e.g. antidepressants), but also to help in the crystallization of this particular GPCR. Therefore, based on our broad experience topic, we have prepared eighteen di-aryl (phenyl and/or pyridin-2-yl) mono- or di-substituted guanidines and 2-aminoimidazolines. The vitro ...