نتایج جستجو برای: gsh depletion

تعداد نتایج: 71935  

Journal: :Zeitschrift fur Naturforschung. C, Journal of biosciences 1987
A Prox J Schmid J Nickl G Engelhardt

Glutathione (GSH) adducts and consecutive degradation products thereof are indications of reactive intermediates during drug metabolism. As demonstrated with the analgesic SX-PP 16 (4-amino-3,5-dibromacetanilide), however, interactions of a drug with GSH can be detected by labelling the GSH-stores with labelled cysteine, and consecutive administration of the unlabelled drug even at therapeutic ...

2013
Charlotte Gauthier Csilla Ozvegy-Laczka Gergely Szakacs Balazs Sarkadi Attilio Di Pietro

ABCG2 is a key human ATP-binding cassette (ABC) transporter mediating cancer cell chemoresistance. In the case of ABCC1, another multidrug transporter, earlier findings documented that certain modulators greatly increase ABCC1-mediated glutathione (GSH) efflux and, upon depletion of intracellular GSH, induce "collateral sensitivity" leading to the apoptosis of multidrug resistant cells. Recentl...

Journal: :iranian journal of pharmaceutical research 0
zahra hami 1- department of pharmacology, school of medicine, tehran university of medical sciences, tehran, iran. 2- department of medical nanotechnology, school of advanced technologies in medicine, tehran university of medical sciences, tehran, iran. mohsen amini department of medicinal chemistry, faculty of pharmacy and drug design and development research center, university of medical sciences, tehran, iran. amir kiani department of pharmacology, toxicology and medical services, school of pharmacy, kermanshah university of medical sciences, kermanshah, iran. mahmoud ghazi-khansari department of pharmacology, school of medicine, tehran university of medical sciences, tehran, iran.

glutathione (gsh) is one of the most important antioxidants that plays an essential role in detoxification of reactive oxygen species (ros) which oxidizes to glutathione disulfide (gssg). paraquat (pq), awidely used herbicide, causes pulmonary injury with the productionof ros. excessive ros accumulation as a consequence of pq exposure are frequently targeted by gsh thereby oxidative stress lead...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2002
Kirk A Tacka James C Dabrowiak Jerry Goodisman Abdul-Kader Souid

The kinetics of the reactions of glutathione (GSH) with 4-hydroperoxycyclophosphamide (4OOH-CP) and acrolein, a metabolite of 4OOH-CP, were investigated in a cell-free medium (pH approximately 7.5) and peripheral blood mononuclear cells. The ability of the thiol drugs, sodium 2-mercaptoethane sulfonate (mesna) and S-2-(3-aminopropylamino)ethanethiol (WR-1065), to affect the reactions of cellula...

Journal: :Molecular pharmacology 1998
Q Chen A I Cederbaum

Two Hep G2 subclones overexpressing CYP2E1 were established with the use of transfection and limited dilution screening techniques. The Hep G2-CI2E1-43 and -47 (E47) cells (transduced Hep G2 subclones that overexpress CYP2E1) grew at a slower rate than parental Hep G2 cells or control subclones that do not express CYP2E1, but remained fully viable. When GSH synthesis was inhibited by treatment ...

Journal: :iranian journal of toxicology 0
سیدعلی هاشمی seyed ali hashemi department of clinical biochemistry, tarbiat modares university, tehran, iran.‎ عبدالامیر علامه abdolamir ‎ allameh department of clinical biochemistry, tarbiat modares university, tehran, iran.‎ بهرام دارایی bahram daraei department of toxicology, tarbiat modares university, tehran, iran.‎ کامران مرادی پینوندی kamran moradi peynevandi ‎ department of plant physiology, tarbiat modares university, tehran, iran.‎ رامین پاشازاده ramin pashazadeh‎ department of chemistry, tarbiat modares university, tehran, iran.‎

background: acetaminophen (apap) overdose causes renal and hepatic injury. it is ‎also believed that oxidative stress has a pivotal role in apap-induced renal injury. ‎therefore, protective effects of different antioxidants have been examined in apap-‎induced renal and hepatic toxicity models. stevia rebadiana is a plant with a high ‎degree of natural antioxidant activity in its leaf extract. t...

Journal: :Teratology 1995
R Hiranruengchok C Harris

Protein-glutathione mixed disulfide (protein-S-SG) formation was investigated in developing rat conceptuses during early organogenesis (gestational day 10, GD 10) using the whole embryo culture system. Low levels of protein-S-SG (25.0 +/- 6.6 pmoles resolved GSH/conceptus) were found in conceptuses under normal culture conditions. Incubation of the conceptuses with 75-500 microM diamide (a thio...

2014
Fiona Shaughnessy Erika Mariotti Karen P Shaw Thomas R Eykyn Philip J Blower Richard Siow Richard Southworth

BACKGROUND The trapping mechanisms of the PET hypoxia imaging agent copper(II)-diacetyl-bis(N (4)-methylthiosemicarbazone) ((64)Cu(ATSM)) remain unresolved, although its reduction prior to dissociation may be mediated by intracellular thiols. Glutathione (GSH) is the most abundant intracellular thiol, and its redox status changes in cancer cells and ischaemic myocardium (two prime applications ...

2010
H Kirana BP Srinivasan

Significant depletion of glutathione (GSH-reduced form) was observed in type 2 diabetes due to oxidative stress. Hence the present study was aimed to investigate a drug which restores GSH along with its anti-diabetic activity. Aqueous extract of Garcinia indica at a dose of 100 mg/kg and 200 mg/kg was given orally to streptozotocin-induced type 2 diabetic rats for a period of 4 weeks. At the en...

Journal: :Toxicological sciences : an official journal of the Society of Toxicology 1998
J L Nieusma D J Claffey J A Ruth D Ross

1,3-Butadiene (BD), a gas used widely in production and synthesis of rubber, plastics, and resins, is metabolized to three different epoxide metabolites: butadiene monoxide (BMO), butadiene bisoxide (BBO) and epoxybutanediol (ED). We have examined the role of stereochemistry in the chemical and enzyme-mediated conjugation of R- and S-BMO; RR-, SS-, and meso-BBO; and SR-, RS-, RR-, and SS-ED wit...

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