Emergence of tumor resistance to an anti-cancer therapy directed against a putative target raises several questions including: (1) do mutations in the target/pathway confer resistance? (2) Are these mutations pre-existing? (3) What is the relative fitness of cells with/without the mutation? We addressed these questions in patients with metastatic colorectal cancer (mCRC). We conducted an exhaus...

Simultaneous indirect assessment of multiple and diverse plant parameters in an exact and expeditious manner is becoming imperative in irrigated arid regions, with a view toward creating drought-tolerant genotypes or for the management of precision irrigation. This study aimed to evaluate whether spectral reflectance indices (SRIs) in three parts of the electromagnetic spectrum ((visible-infrar...

in order to study the effect of deficit irrigation at reproductive growth stages on growth and grain yield of four sunflower cultivars namely: azargol, allstare, alison and euroflor, an experiment was conducted during the 2007 growing season at the experimental field of the agricultural faculty of bu-ali sina university. the experimental design was a split plot one, based upon a randomized comp...

in order to study the yield and growth indices of spring safflower as double cropping, an experiment was carried out in 2007 at the research farm of faculty of agriculture, yasouj university, iran. the experiment was a factorial based on randomized complete block design with three replications. factors included of combination of four sowing dates (may 16, june1, june 16 and july 2) and four cul...

ecological studies based on field data have shown that vegetation phenology follows a relatively well-defined temporal pattern. this pattern, that is reflecting the cumulative temperature from the date of the beginning of the growth, can be represented by the use of a suitable model. due to the spatial, temporal, and ecological complexity of these processes a simple method to monitor phenologic...

foliar analysis of natural deciduous tree species of basswood (tilia americana l.) (ba), american beech (acer grandifolia enrh) (be), and white ash (fraxinus americana l.) (wa) was carried out in 1994 in southern quebec. the diagnosis and recommendation integrated system (dris) was developed from the traditional method to find the preliminary norm and indices of n, p, k, ca, and mg for the ...

BACKGROUND Growth is one of the most important indices in child health. The best and most effective way to investigate child health is measuring the physical growth indices such as weight, height and head circumference. Among these measures, weight growth is the simplest and the most effective way to determine child growth status. Weight trend at a given age is the result of cumulative growth e...

Piecewise growth curvemodel (PGCM) is often usedwhen the underlying growth process is not linear and is hypothesized to consist of phasic developments connected by turning points (or knots or change points). When fitting a PGCM, the conventional practice is to specify turning points a priori. However, the true turning points are often unknown and misspecifications of turning points may occur. T...