Treatment with growth factors is an effective method to promote wound healing. Several growth factors have been used in wound treatment, including basic fibroblast growth factor (bFGF) discovered in the 1970s, platelet-derived growth factor (PDGF), epidermal growth factor (EGF), and bone morphogenetic protein (BMP). In 2001, Kaken Pharmaceutical Co., Ltd. launched Fiblast Spray in Japan. This p...

Several growth factors are potential mediators of wound healing, although their actual roles, interactions, and therapeutic use are not established. Six well-characterized human growth factors were chosen for detailed investigation by topical application to standardized skin wounds in swine: epidermal growth factor (EGF), transforming growth factors a and B (TGF-a and TGF), fibroblast growth fa...

ANTONIO FRANCAVILLA. MO, PhD, LUIGI POLIMENO, PhD, MICHElE BARONE, MD, ALESSANDRO AZZARONE, MO, AND THOMAS E. STARZL, MO, PhD From the Department of Gastroenterology, University of Bari, Bari, Italy (A.F., L.P., M.B., A.A.), and the Department of Surgery, University Health Center of Pittsburgh, University of Pittsburgh, and the Veterans Administration Medical Center, Pittsburgh, Pennsylvania (T...

Insulin-like growth factor I (IGF I) is an important mitogen for vascular smooth muscle cells. To characterize regulation of vascular IGF I receptors, we performed radioligand displacement experiments using rat aortic smooth muscle cells (RASMs). Serum deprivation for 48 hours caused a 401% decrease in IGF I receptor number. Exposure of quiescent RASMs to platelet-derived growth factor (PDGF), ...

Cell division, cell death, and cell differentiation are hallmarks of embryogenesis. Such processes are supported by neurotrophins that have the capacity of regulating not only developmental processes, but also neuronal survival, morphological adaptation, and neural plasticity. Nerve growth factor (NGF) is a prototype of neurotrophins capable of influencing survival and differentiation of neuron...

We have approached the study of growth factors affecting cartilage and bone development by investigating those factors present in bone which are able to initiate new cartilage and bone formation in vivo. This has led to the identification and molecular cloning of seven novel human factors which we have named BMP-1 through BMP-7. Six of these molecules are related to each other, and are also dis...

this manuscript reviews the present knowledge related to folliculogenesis in sheep.folliculogenesis starts with formation of primordial follicles before birth, present as a pool containing a certain number of follicles. by the attainment of puberty, a group of follicles from that pool starts to grow, a process known as primordial follicle activation or recruitment. the number of growing primord...

Synapses are increasingly recognized as key structures that malfunction in disorders like schizophrenia, mental retardation, and neurodegenerative diseases. The importance and complexity of the synapse has fuelled research into the molecular mechanisms underlying synaptogenesis, synaptic transmission, and plasticity. In this regard, neurotrophic factors such as netrin, Wnt, transforming growth ...

Growth and pattern formation occur simultaneously in many epimorphic fields and it has been suggested that specification of positional information is somehow linked to cell division. It is possible, therefore, that boundary regions responsible for the specification of positional information produce cell growth factors. In this paper I review the properties of some known growth factors, describe...

Enhancement of wound healing was limited to good surgical technique, maintenance of a clean wound with appropriate dressings, and debridement. The ability to heal wounds has been advanced through the recognition that healing in a moist environment is improved over that of a desiccated wound. Pharmacologic approaches to wound healing did not exist until the last few decades, when it was recogniz...