نتایج جستجو برای: granzyme h
تعداد نتایج: 533304 فیلتر نتایج به سال:
The granules of effector cytotoxic CD8 cells and natural killer (NK) cells contain a family of serine proteases called granzymes (granule-secreted enzymes) [5]. Granzymes are stored in the cytotoxic granules and require perforin to be delivered into the target cells to exert their cytotoxic function [5, 6]. Granzymes can also be released to the extracellular space and cleave extracellular matri...
It is widely assumed that the development of memory CD8 T cells requires the escape of CTLs from programmed cell death. We show in this study that although serine protease inhibitor 6 (Spi6) is required to protect clonal bursts of CTLs from granzyme B-induced programmed cell death, it is not required for the development of memory cells. This conclusion is reached because memory cell precursors ...
BACKGROUND Granzymes are a subfamily of serine proteases involved in the pathogenesis of many inflammatory disorders. In contrast with granzyme A and B, the role of granzyme K (GrK) in human lung diseases is unknown. Therefore, the release and expression of GrK in allergic asthma, chronic obstructive pulmonary disease (COPD) and bronchopneumonia were investigated. METHODS Soluble GrK was quan...
Human plasmacytoid dendritic cells (pDC) are important modulators of adaptive T cell responses during viral infections. Recently, we found that human pDC produce the serine protease granzyme B (GrB), thereby regulating T cell proliferation in a GrB-dependent manner. In this study, we demonstrate that intrinsic GrB production by pDC is significantly inhibited in vitro and in vivo by clinically u...
The granules of effector cytotoxic CD8 cells and natural killer (NK) cells contain a family of serine proteases called granzymes (granule-secreted enzymes) [5]. Granzymes are stored in the cytotoxic granules and require perforin to be delivered into the target cells to exert their cytotoxic function [5, 6]. Granzymes can also be released to the extracellular space and cleave extracellular matri...
Tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) frequently complicates combined antiretroviral therapy and antituberculosis therapy in HIV-1-coinfected tuberculosis patients. The immunopathological mechanisms underlying TB-IRIS are incompletely defined, and improved understanding is required to derive new treatments and to reduce associated morbidity and mortality....
In adoptive therapy, CD8 T cells expressing active STAT5 (STAT5CA) transcription factors were found to be superior to unmanipulated counterparts in long-term persistence, capacity to infiltrate autochthonous mouse melanomas, thrive in their microenvironment, and induce their regression. However, the molecular mechanisms sustaining these properties were undefined. In this study, we report that S...
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