Radio-iodinated m-iodobenzylguanidine (MIBG), an analogue of the neurotransmitter norepinephrine (NE), is increasingly used in the diagnosis and treatment of neural crest tumors. Active uptake and subsequent retention of MIBG and NE was studied in human neuroblastoma SK-N-SH cells. Neuron-specific uptake of [125I]MIBG and [3H]NE saturated at extracellular concentration of 10(-6) M and exceeded ...

The defense reactions against biological (Histoplasma capsulatum and Escherichia coli) and non-biological materials (China ink and nylon thread) were tested in vivo in third instar larvae of Dermatobia hominis. The cellular defense performed by larval hemocytes was observed under electron microscopy. China ink particles were phagocytosed by granular cells 5 h after injection. E. coli cells were...

Rat pancreatic islets have been studied following successive daily administration of dehydroascrobic acid (DHA) and during the recovery phase following 3 daily injections. One injection of DHA produces degranulation of B cells seen in the light microscope as a loss of aldehyde fuchsin positivity. In the electron microscope the B cells appear to have secretory granules accumulated subjacent to t...

A rare case of granular cell myoblastoma is reported in a 37-year-old man where the tumour was situated within the medial rectus muscle. Histological, cytochemical and ultrastructural examination showed it to have features typical of granular cell myoblastoma. It also reacted with chorioembryonic antigen antisera, a sign of primitive cell origin. The findings add further weight to the idea of t...

Oncocytoma is a rare benign salivary gland tumor, which mostly occurs in the parotid gland. In this article, we describe an early onset of oncocytoma of minor salivary gland in a 36-year, white male. On clinical examination, we encounter with a painless, granular, sessile mass. After Excisional biopsy, the histopathological features revealed sheets of cells with abundant granular eosinophilic c...

Objective. Granular cell tumors arise from neurogenic mesenchymal stem cells and can occur anywhere throughout the body. They rarely present as breast masses and should be included in the differential diagnosis of pediatric breast neoplasms. We report a rare presentation of a pediatric breast granular cell tumor and a review of the literature. Participant. A 15-year-old female presented with an...

Insulin secretion from pancreatic beta cells is dependent on maturation and acidification of the secretory granule, processes necessary for prohormone convertase cleavage of proinsulin. Previous studies in isolated beta cells revealed that acidification may be dependent on the granule membrane chloride channel ClC-3, in a step permissive for a regulated secretory response. In this study, immuno...

BACKGROUND Most of crustacean immune responses are well described for the aquatic forms whereas almost nothing is known for the isopods that evolved a terrestrial lifestyle. The latter are also infected at a high prevalence with Wolbachia, an endosymbiotic bacterium which affects the host immune system, possibly to improve its transmission. In contrast with insect models, the isopod Armadillidi...

The rat protein kinase C substrate neurogranin has a granular distribution in cortical and hippocampal neurons. We demonstrate that in these cells, granular labelling corresponds to a local concentration of neurogranin-immunoreactivity at both the membranes of mitochondria and trans-Golgi vesicles and soma-proximal dendritic shaft and spinal head structures. Our findings suggest that the functi...

an improved chemical regeneration of the granular activated carbon (gac) exhausted by the color (pigments and pollutants) from citric acid fermentation solution (caf) was investigated. in the experiments, improved means were adopted to advance the traditional chemical regenerating method and the adsorption capacity of the first time renewed gac is 103% of original gac. using oxidant and surfact...