Maternally inherited bacteria of the genus Volbachia can cause cytoplasmic incompatibility resulting in the developmental arrest of early embryos. Previous studies have shown that both single- and superinfections of Wolbachia naturally occur in populations of Aedes albopictus (Skuse). Here, we report crossing experiments using three infection types occurring in Ae. albopictus: uninfected, singl...

Following the identification of the male (S-locus Cysteine Rich/S-locus Protein 11) and female (S Receptor kinase [SRK]) factors controlling self-incompatibility in the Brassicaceae, research in this field has focused on understanding the nature of the cellular responses activated by these regulators. We previously identified the ARM Repeat Containing1 (ARC1) E3 ligase as a component of the SRK...

T2-type RNases are responsible for self-pollen recognition and rejection in three distantly related families of flowering plants-the Solanaceae, Scrophulariaceae, and Rosaceae. We used phylogenetic analyses of 67 T2-type RNases together with information on intron number and position to determine whether the use of RNases for self-incompatibility in these families is homologous or convergent. Al...

BACKGROUND There are conflicting reports on the effect of donor-recipient HLA matching on outcomes in heart transplantation. The objective of this study was to investigate the effects of HLA-A matching relative to HLA-B and -DR matching on long-term survival in heart transplantation. METHODS A total of 25 583 patients transplanted between 1988 and 2011 were identified from the International S...

EVOLUTION OF HYBRID INCOMPATIBILITIES IN GENE REGULATORY NETWORKS SEPTEMBER 2013 ALEXANDER Y. TULCHINSKY, B.S., VIRGINIA COMMONWEALTH UNIVERSITY, RICHMOND M.S., VIRGINIA COMMONWEALTH UNIVERSITY, RICHMOND Ph.D., UNIVERSITY OF MASSACHUSETTS, AMHERST Directed by: Adam H. Porter Under the Dobzhansky-Muller model, postzygotic isolation results from incompatibility between interacting genes. Evidence...

A major mechanism for bacterial resistance to antibiotics is through the acquisition of a plasmid coding for resistance-mediating proteins. Described herein is a strategy to eliminate these plasmids from bacteria, thus resensitizing the bacteria to antibiotics. This approach involves mimicking a natural mechanism for plasmid elimination, known as plasmid incompatibility. The compound apramycin ...

The genetic basis of vegetative incompatibility in the cellular slime mold, Dictyostelium discoideum, is elucidated. Vegetatively compatible haploid strains from parasexual diploids at a frequency of between 10(-6) and 10(-5), whereas "escaped" diploids are formed between vegetatively incompatible strains at a frequency of approximately 10(-8). There is probably only a single vegetative incompa...

Uncovering the genetic and molecular basis of barriers to gene flow between populations is key to understanding how new species are born. Intrinsic postzygotic reproductive barriers such as hybrid sterility and hybrid inviability are caused by deleterious genetic interactions known as hybrid incompatibilities. The difficulty in identifying these hybrid incompatibility genes remains a rate-limit...

Many different blood group systems, such as Rh, ABO, Kell, Kidd, Duffy, MNS, have been reported as causes of hemolytic disease of the newborn. Hemolysis due to minor blood group incompatibility in the fetus or newborn has been determined in isolated case reports. Here, we report a case of a patient who had received red cell transfusion due to severe Rh c and E incompatibility, leading to hemoly...

Callus tissues induced from shoots of species in the orange subfamily (Aurantioideae) were grafted in vitro to evaluate the correlation between reaction at the callus graft interface and taxonomic relationship. The graft interface between two pieces of callus from species that are taxonomically close was not distinguishable by anatomical observations. On the other hand, in the combinations of l...