We assessed the occurrence of atypical adenomatous hyperplasia (AAH) in whole lung lobes with primary cancer lesions. Following surgical resection, tissue specimens were sliced to a thickness of 4 mm (3,641 specimens from 61 cases; mean = 59.7 specimens per case). A total of 119 AAH foci were found and an association was evident in 25 (57%) of 44 adenocarcinomas, 3 (30%) of 10 squamous cell car...

Barrett's esophagus is a condition in which the normal squamous lining of the esophagus has been replaced by columnar epithelium containing intestinal metaplasia induced by recurrent mucosal injury related to gastroesophageal reflux disease. Barrett's esophagus is a premalignant condition that can progress through a dysplasia-carcinoma sequence to esophageal adenocarcinoma. Multiple endoscopic ...

BACKGROUND The pathogenesis of salivary gland carcinomas is very complex and prognostic markers are difficult to find in these carcinomas of which the different subtypes have varying malignant potential. The study was conducted to examine the cellular distribution of maspin and MCM2 in salivary gland carcinomas and their value to predict lymph node metastasis. MATERIALS AND METHODS Fifty thre...

Background: Prostatic cancer is highly ominous in men and survives hormonal insufficiency. We studied Androgen Receptor (AR) expression various Gleason scores (GS) of prostatic adenocarcinoma by using immunohistochemistry.
 Materials methods: This descriptive analytical study was carried out at King Edward Medical University/Mayo Hospital, Lahore 2016. Slides were prepared from 60 paraffin...

BACKGROUND Barrett's esophagus (BE) is the most important identifiable risk factor for the progression to esophageal adenocarcinoma. METHODS This article reviews the current endoscopic therapies for BE with high-grade dysplasia and intramucosal cancer and briefly discusses the endoscopic palliation of advanced esophageal cancer. RESULTS The diagnosis of low-grade or high-grade dysplasia (HG...

Esophageal adenocarcinoma is an aggressive malignancy with a poor prognosis. In Western countries, the incidence of esophageal adenocarcinoma has increased dramatically in the last three decades. To improve patient survival and reduce disease burden, early-stage detection, or better yet, preventing the progression of esophageal adenocarcinoma from its premalignant lesions, constitute the best s...

The CT and MR appearance of a case of low-grade adenocarcinoma of probable endolymphatic sac origin is presented. The tumor destroyed a large part of the posterior temporal bone and showed prominent extension into the posterior cranial fossa.

BACKGROUND: Most prevalent esophageal neoplasm is squamous cell carcinoma and adenocarcinoma. Other tumors are uncommon and poorly studied. Primary neuroendocrine esophageal neoplasm is a rare carcinoma and most of its therapy management is based on lung neuroendocrine studies. Neuroendocrine tumors can be clustered in the following subtypes: high grade (small cell carcinoma or large cell carc...