The activity of cytochrome p450 isozyme 3A4 (CYP3A4) enzyme and P-glycoprotein (P-gp) is modulated by grapefruit juice and herbal drugs. CYP3A4 is the major phase I drug metabolizing enzyme and P-gp is an ATP-dependent drug efflux pump that regulates the intestinal absorption of orally administered drugs. Honey is commonly consumed as a dietary supplement. However, its influence on human CY...

Introducing inequality constraints in Gaussian process (GP) models can lead to more realistic uncertainties in learning a great variety of real-world problems. We consider the finite-dimensional Gaussian approach from Maatouk and Bay (2017) which can satisfy inequality conditions everywhere (either boundedness, monotonicity or convexity). Our contributions are threefold. First, we extend their ...

QSO absorption spectra provide an extremely useful probe of possible cosmological variation in various physical constants. Comparison of H i 21 cm absorption with corresponding molecular (rotational) absorption spectra allows us to constrain variation in y ≡ α2gp where α is the fine structure constant and gp is the proton g-factor. We analyse spectra of two QSOs, PKS1413+135 and TXS 0218+357, a...

in recent years according to the growing companies andproducts supplied, and competition between them has intensified. productsand diversity, one of the main concerns of commercial institutions.therefore, selecting the media to introduce and is important therelationship between customers’ products. given the multiplicity of mediain promoting and marketing the products, they are the optimalchoic...

this work is a continuation of [a‎. ‎o‎. ‎asar‎, ‎‎‎on infinitely generated groups whose proper subgroups are solvable‎, ‎{em j‎. ‎algebra}‎, ‎{bf 399} (2014) 870-886.]‎, ‎where it was shown‎ ‎that a perfect infinitely generated group whose proper subgroups‎ are solvable and in whose homomorphic images normal closures of ‎finitely generated subgroups are residually nilpotent is a fitting‎‎$p$-g...

Equine arteritis virus (EAV) is an enveloped, positive-stranded RNA virus belonging to the family Arteriviridae of the order Nidovirales. EAV particles contain seven structural proteins: the nucleocapsid protein N, the unglycosylated envelope proteins M and E, and the N-glycosylated membrane proteins GP(2b) (previously named G(S)), GP(3), GP(4), and GP(5) (previously named G(L)). Proteins N, M,...