Indian manufacturing firms operating in rapidly changing and highly competitive market, over the last few decades, have embraced organization-wide transformation to achieve cultural and operational excellence. In recent years, numerous approaches have been proposed to improve business and manufacturing performance. Lean practices in particular, Total Productive Management (TPM) and Total Qualit...

Abstract Manufacturing companies must find competitive methods to produce products cheaper, faster and better to continuously satisfy their customers and acquire organizational success. For continuous improvement to be more successful, hybrid programs such as integrated TQM and JIT approaches give better results. As the existing TQM and JIT integrated approaches in literatures are not analogous...

Haematopoietic stem cell (HSC) gene therapy has demonstrated potential to treat many diseases. However, current state of the art requires sophisticated ex vivo gene transfer in a dedicated Good Manufacturing Practices facility, limiting availability. An automated process would improve the availability and standardized manufacture of HSC gene therapy. Here, we develop a novel program for semi-au...

Industry practices in environmentaly sustainable manufacturing have emerged in various ways in different regions around the world. Depending on local environmental requirements companies have adopted practices with different priorities and different intensity. An industry survey in three regions of the world was conducted with the aim to find out what the current trends and differences of indus...

This dissertation approaches the question of sustainability and its influence on company performance, with special focus on the manufacturing industry. In the contemporary production environment, manufacturing operations must take into account not only profit, but also environmental and social performance, in order to ensure the long-term development of the company. Companies have to decide whe...

Cleaning validation, a requirement of the current Good Manufacturing Practices (cGMP) for Drugs, consists of documented evidence that cleaning procedures are capable of removing residues to predetermined acceptance levels. This report describes a strategy for the selection of the worst case product for the production of lyophilized reagents (LRs) for labeling with 99mTc from the Instituto de Pe...