Since the pioneering work of Everett and Sawyer, the idea that pituitary gonadotrophins provide the critical timing cue for ovulation has remained unquestioned [1]. It is widely accepted that the timing of ovulation depends entirely on the timing of luteinizing hormone (LH) secretion, itself driven by neuroendocrine releasing factors controlled by the circadian clock in the suprachiasmatic nucl...

Most published work on the binding of gonadotrophins to testicular tissue has been based on a biochemical approach and whole organs, homogenates or subcellular fractions have been used. Some studies have been concluded on interstitial tissue and/or seminiferous tubules separated from each other by microdissection after the method of Christensen & Mason (1965). Binding of radioiodinated HCG to s...

Objectives: To determine the effectiveness of gonadotrophins administration to men with idiopathic subfertility on spontaneous pregnancy rate and in assisted reproductive techniques. Search strategy: We searched the all relevant databases. Searches were not limited by language. The bibliographies of included, excluded trials and abstracts of major meetings were searched for additional trials. A...

Metronidazole and it’s derivatives are drugs that have both antiprotozoal and anti bacterial effect.The reproductive toxicity of metronidazole has been shown in some studies. To investigate the effect of metronidazole on spermatogenesis in adult male rats, this study was designed. Eighteen wistar male rats (70-90days old) were randomly divided into three groups. Animals in group I (Control grou...