21 kilometres north of Stewart (Figure 2-IZ-l), on the east The Silbak Premier mine is in northwest British Columbia, side of the Salmon River Valley. The original discovery of a that from 1918 to 1953 produced 4.3 million tonnes of ore high-grade vein in 1910 culminated in an underground mine grading 14.6 grams gold and 304 grams silver per tonne from sulphide-bearing stockworkveins and brecci...

The first general open-flask synthesis of amine-boranes with inexpensive and readily available reagents, such as sodium borohydride, sodium bicarbonate, water, and the desired amines is described. Even amines bearing borane-reactive functionalities, such as alkene, alkyne, hydroxyl, thiol, ester, amide, nitrile, and nitro are well tolerated. Some of these novel amine-boranes represent stable mo...

SUMMARY The clearance of colloidal carbon from the blood stream of rats bearing methylcholanthrene-induced sarcomas has been studied. Growth of both primary and isotransplanted tumors greatly enhances the clearance of carbon. This effect is greater with increasing tumor size. The uptake of radioactive colloidal gold has been studied following intravenous injection. The final distribution of col...

A tandem gold-catalyzed cycloisomerization/Suzuki cross coupling sequence involving arylethynyl-N-methyliminodiacetic acid boronates is described. Combining the mildness of homogeneous gold catalysis with the versatility of N-methyliminodiacetic acid (MIDA) boronates, this tandem two-step method enables the rapid assembly of various aryl-substituted heterocycles without having to isolate or pur...

Dihydrobenzo[a]fluorene derivatives have been prepared by a formal intramolecular [3 + 3] cycloaddition of o-alkynylstyrenes bearing a secondary alkyl group at the β-position of the styrene moiety. The process, catalyzed by a cationic gold(I) complex, involves a 1,2-hydride migration as the key step. 6,11-Dihydro-5H-benzo[a]fluorenes could be obtained from the initially generated 6,6a-dihydro-5...

Encapsulation of the anticancer gold(III) complexes bearing porphyrin or Schiff-base ligands by gelatin-acacia microcapsules confers both sustained-release and rapid-release properties, improved solution stability and/or in vivo efficacy compared to that using the unencapsulated complexes alone.

The scope and limitations of gold-catalyzed tandem cycloisomerization/fluorination reactions of unprotected 2-alkynylanilines to have access to 3,3-difluoro-2-aryl-3H-indoles and 3-fluoro-2-arylindoles are described. An unprecedented aminoauration/oxidation/fluorination cascade reaction of 2-alkynylanilines bearing a linear alkyl group on the terminal triple bond is reported.

An efficient one-pot nitro-Mannich/hydroamination cascade reaction for the synthesis of substituted pyrrolidines bearing three stereocentres is reported. Proceeding under the control of a combination of base and gold(I) catalysts, the cascade reaction affords the pyrrolidine products in high yields with good to excellent diastereoselectivities.

The synthesis and characterization of a new class of cationic (NHC)gold(I) (NHC = N-Heterocyclic carbene) complex containing the phosphate counterions TRISPHAT and TRISPHAT-N have been achieved. The selection of the appropriate hexacoordinated phosphate architecture permits the isolation of complexes bearing an inner or outer sphere anionic counterion.

A series of 3-allenyl benzo[b]thiophenes were synthesized through a gold(I)-catalyzed domino reaction. The process consists in 5-endo-dig cyclization with C−S bond formation and consecutive S-to-C propargyl migration via [3,3]-sigmatropic Claisen rearrangement. With aryl substituents on both triple bonds the substrate, subsequent intramolecular hydroarylation formed allenyl system led to 3-inde...