Reactive immunization with a single-dose cholera vaccine that could rapidly (within days) protect immunologically-naïve individuals during "virgin soil" epidemics would facilitate cholera control. One dose of attenuated Vibrio cholerae O1 classical Inaba vaccine CVD 103-HgR (Vaxchora™) containing ≥2x108 colony forming units (cfu) induces vibriocidal antibody seroconversion (correlate of protect...

Immunoglobulin G (IgG) antibodies to Epstein-Barr virus (EBV) nuclear antigens 2 and 1 (EBNA-2 and EBNA-1, respectively) were studied using sera from healthy individuals of a population with a high incidence of asymptomatic primary EBV infections during infancy or childhood in Japan. Two CHO-K1 cell lines expressing EBNA-2 and EBNA-1 were used for anticomplement and indirect immunofluorescence ...

A live attenuated zoster vaccine (ZOSTAVAX™, Merck & Co., Inc.) was approved by the Korea Ministry of Food and Drug Safety in 2009. However, the immunogenicity and safety of the vaccine has not been assessed in Korean population. This is multi-center, open-label, single-arm study performed with 180 healthy Korean adults ≥ 50 yr of age. The geometric mean titer (GMT) and geometric mean fold rise...

background malnutrition is the most common cause of immune deficiency. it results in reduced secretion of t-cells and b-cell-stimulating factors leading to declining of special immunoglobulins. on the other hand, hepatitis b, as a major world health problem, can be prevented effectively by vaccination. three doses of hepatitis b virus (hbv) vaccine induce protective levels of anti-hepatitis b s...

We propose a rigorous approach for the inverse design of functional photonic structures by coupling adjoint optimization method and two-dimensional generalized Mie theory (2D-GMT) multiple scattering problem finite-size arrays dielectric nanocylinders optimized to display desired functions. refer these as "photonic patches". briefly introduce formalism 2D-GMT critical steps necessary implement ...

BACKGROUND Exaggerated vasoconstriction plays a very important role in the hypertension, a major component of metabolic syndrome (MetS). In the current work, the potential protective effect of methanol extract of fruit hulls of Garcinia mangostana L. on the exaggerated vasoconstriction in MetS has been investigated. In addition, the bioactive fraction and compounds as well as the possible mecha...

Intranasal (i.n.) vaccination with two suboptimal doses of 8 microg of deglycosylated chain A ricin (DGCA) stimulated low anti-ricin ELISA IgG and neutralizing antibody responses and the vaccine was only marginally protective against a lethal ricin toxin aerosol challenge. However, in the presence of 4, 2, or 1 microg of the mucosal adjuvant LTR72, a mutant of the heat-labile enterotoxin of Esc...

Background. Previous studies have demonstrated the superior immunogenicity of high-dose inactivated influenza vaccine (IIV-HD) in older adults compared to standard-dose inactivated influenza vaccine (IIV-SD), as measured by hemagglutination inhibition (HAI) antibody titers against egg-propagated vaccine antigens. The 20122013 northern hemisphere influenza season was characterized by high H3N2 a...

Diminished immune response after vaccination occurs in cancer patients. This observational study evaluated the and safety profile COVID-19 radiotherapy The comprised 53 patients undergoing voluntarily received vaccine. two regimens were homologous ChAdOx1-S recombinant (AstraZeneca, AZ), “AZ-AZ” heterologous “AZ-mRNA”. seroconversion rate anti-RBD immunoglobulin geometric mean titers (GMT) asse...

Immunol®(syrup) (0.65ml/kg), Gen-Xing®(tablet) (7.2mg/kg) and MufarrehYakuuti® (semi-solid) (87mg/kg) were administered orally at normal, 25% (0.82ml/kg, 9mg/kg 107.5mg/kg) 50% (0.98ml/kg, 10.8mg/kg 129mg/kg) increased dose to healthy male rabbits for two weeks. Non-specific Humoral immune responses measured throughpercent Neutrophil Adhesion assay Haemagglutination Antibody against Sheep RBCsr...