نتایج جستجو برای: glycogen synthase kinase
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The present study investigated the effect of 1-Deoxynojirimycin (DNJ) on liver injury and hepatic glucose metabolism in db/db mice. Mice were divided into five groups: normal control, db/db control, DNJ-20 (DNJ 20 mg·kg(-1)·day(-1)), DNJ-40 (DNJ 40 mg·kg(-1)·day(-1)) and DNJ-80 (DNJ 80 mg·kg(-1)·day(-1)). All doses were treated intravenously by tail vein for four weeks. DNJ was observed to sign...
?-Amyloid (A?) elevation, tau hyperphosphorylation, and neuroinflammation are major hallmarks of Alzheimer’s disease (AD). Glycogen synthase kinase-3? (GSK-3?) is a key protein kinase implicated in the pathogenesis AD. Blockade GSK-3? an attractive therapeutic strategy for Isoorientin, 6-C-glycosylflavone, was previously shown to be highly selective inhibitor GSK-3?, while exerting neuroprotect...
Glycogen synthase kinase 3 (GSK-3) is a key component of the Wnt signalling pathway, among others, and is known to be regulated by inhibition. Now a novel, dual specificity protein kinase known as Zaphod kinase has been discovered that activates GSK-3 by tyrosine phosphorylation.
Down syndrome (DS) results from trisomy of human chromosome 21 (Hsa21) and is associated with an increased risk of Alzheimer's disease (AD). Here, using the unique transchromosomic Tc1 mouse model of DS we investigate the influence of trisomy of Hsa21 on the protein tau, which is hyperphosphorylated in Alzheimer's disease. We show that in old, but not young, Tc1 mice increased phosphorylation o...
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