This study was designed to test the glucose metabolic and vasodilator actions of insulin in rats and its relation to cholinergic system-dependent mechanisms. The first group of rats had pulsed Doppler flow probes and intravascular catheters implanted to determine blood pressure, heart rate, and regional blood flows. Insulin sensitivity was assessed by the euglycemic-hyperinsulinemic clamp techn...

Effect of high-dose insulin analog initiation therapy was evaluated on lipid peroxidation and oxidative stress markers in type 2 diabetes mellitus (T2DM). Twenty-four T2DM patients with HbA1c levels above 10% despite ongoing therapy with sulphonylurea and metformin were selected. Former treatment regimen was continued for the first day followed by substitution of sulphonylurea therapy with diff...

An insulin delivery system that self-regulates blood glucose levels has the potential to limit hypoglycemic events and improve glycemic control. Glucose-responsive systems have been developed by coupling oxidase with a stimuli-responsive biomaterial. However, challenge of achieving desirable release kinetics (i.e., within minutes after elevation duration on order weeks) still remains. Here, we ...

background: hyperglycemia is one of the important featurs of diabetes. in cell culture studies different methods are used to mimic the hyperglycemia condition. in this study we investigate response of human liver cancer cell line (hepg2) to high insulin, high glucose, and high insulin/ high glucose medium exposure. methods: hepg2 cells were settled in dmem+0.1% fbs or dmem free-serum medium wit...

Pancreatic β-cells dysfunction and impairment of insulin action usually leads to hyperglycemia. Punica granatum L. is a well-known traditional herbal remedy in Iran due to its positive effects on ameliorating blood glucose homeostasis. In this study, we aimed to investigate and compare the pomegranate fruits aqueous extract (PE) on glucose and lipid metabolisms in normal and Alloxan-induced dia...

INSULIN REGIMENS IN DIABETES CONTROL PREGNANT PATIENTS-A RANDOMIZED CLINICAL TRIAL
 Ist Author Samina Aliya Sabir, 2nd Dr Qudsia Qazi, 3rd Ghulam Abbas, Laila Zeb
 Correspondence Author: Sumaira Yasmin
 
 ABSTRACT:
 Objective: To compare the effectiveness of basal bolus and Premixed insulin regimen in gestational type 2 diabetics low resource setting.
 Methodology:...

Objective: Fetal growth is a complex process influenced by environmental and genetic factors. Environmental factors such as glucose, lipids amino acids play role in of the fetus. Glucose, insulin lipid levels cord blood can change birth weight according to gestational age newborn. The aim study examine relationship between newborns with small (SGA), normal (AGA) large (LGA) age. Materials Metho...

background: polycystic ovarian syndrome (pcos) is a common disease among women in fertility ages and cause severe insulin resistance. hyperhomocysteinaemia is said to be among the features of pcos that could influence its outcome. objective: this study aimed to investigate whether hyperhomocysteinaemia exists in pcos and if it is related to insulin resistance in the affected patients. materials...

BACKGROUND Regulation of plasma glucose concentration for type 1 diabetic patients is challenging, and exercise is an added complication. From a metabolic prospective, the significant exercise-induced effects are increased glucose uptake rate by the working tissues, increased hepatic glucose release to maintain overall glucose homeostasis, and decreased plasma insulin concentration. During prol...

Background—Hypertension is associated with impaired glucose metabolism and insulin resistance. Chronic activation of the sympathetic nervous system may contribute to either condition. We investigated the effect of catheter-based renal sympathetic denervation on glucose metabolism and blood pressure control in patients with resistant hypertension. Methods and Results—We enrolled 50 patients with...