نتایج جستجو برای: glomerulonephritis
تعداد نتایج: 12281 فیلتر نتایج به سال:
Chronic infections induced at birth with either LCM, an RNA virus, or polyoma, a DNA virus, in NZB, NZW, and NZB x W mice enhance ANA formation, aggravate the immune complex glomerulonephritis, and increase the associated mortality. The ANA titer was increased without apparent change in specificity of the antibodies involved in all three types of mice. Glomerulonephritis, while more severe in i...
Crescentic glomerulonephritis is mediated by inappropriate humoral and cellular immune responses toward self-antigens that may result from defects in central and peripheral tolerance. Evidence now suggests that regulatory T cells (Tregs) may be of pathophysiological importance in proliferative and crescentic forms of glomerulonephritis. To analyze the role of endogenous Tregs in a T cell-depend...
Anti-glomerular basement membrane disease is characterized by autoimmunity to antigenic sites on type IV collagen of the glomerular basement membrane. The majority of patients present with rapidly progressive glomerulonephritis and alveolar hemorrhage. The occurrence of antiglomerular basement membrane disease and other types of glomerulonephritis, such as membranous nephropathy, IgA nephropath...
Lysosomal membrane protein 2 (LAMP-2) is a target of antineutrophil cytoplasmic autoantibodies (ANCA) in addition to the more commonly known targets proteinase 3 and myeloperoxidase. The prevalence of anti-LAMP-2 antibodies and their relationship to disease in ANCA glomerulonephritis are not well described. We measured anti-LAMP-2 reactivity in 680 sera samples (two academic centers) from patie...
introduction antineutrophil cytoplasmic antibodies (anca)-associated glomerulonephritis (gn) is characterized by necrotizing and crescentic gn with paucity of immunoglobulin (ig) and complement deposition, which is also known as pauci-immune crescentic gn. membranous nephropathy (mn) is characterized by the formation of subepithelial immune deposit with resultant changes in glomerular basement ...
Cryoglobulinemic Glomerulonephritis as a Presentation of Atypical Post-Infectious Glomerulonephritis
BACKGROUND Signal transducer and activator of transcription (STAT) 3 plays an important role in the regulation of cell proliferation. However, the mechanism of STAT3 activation in human glomerulonephritis is unclear. METHODS STAT3 activation was determined using immunohistochemistry for phosphorylated STAT3 (p-STAT3) in normal human kidney and various types of glomerulonephritis. We also iden...
BACKGROUND The involvement of IL-1beta and other pro-inflammatory cytokines in most forms of glomerulonephritis is now well established. The P2X(7) receptor, an ATP-sensitive P2X receptor, functions not only as a non-selective cation channel, but it is also involved in the rapid processing and release of IL-1beta, apoptosis and necrotic cell death. Therefore, we wanted to investigate if express...
Background Chronic kidney disease has become a leading public health concern in China, as it is associated with increased morbidity, mortality, and costs. However, the overall situation regarding common glomerular diseases in China remains unclear. Hence, the aim of this study was to assess the national profile of the common types of glomerulonephritis in China. Methods We searched Medline, E...
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