OBJECTIVE The purpose of this study was to develop a simpler method to measure severely reduced glomerular filtration rate (GFR) for patients with a GFR below 30 mL/min. METHOD The GFR was measured in 24 patients using both the 51Cr EDTA slope-intercept method (the conventional method) and 99mTc-DTPA with our proposed simpler GFRn method. RESULTS The correlation coefficient was 0.92 between...

BACKGROUND The aim of this study was to evaluate the independent roles of proteinuria and reduced estimated glomerular filtration rate (GFR) in the development of acute myocardial infarction in a northern Taiwanese population. METHODS We conducted a community-based prospective cohort study in Keelung, the northernmost county of Taiwan. A total of 63,129 subjects (63% women) ≥ 20 years of age ...

BACKGROUND The increase in glomerular filtration rate (GFR) induced by amino acid infusion is attenuated in rats with chronic renal denervation. The aim of the present study was to investigate whether renal denervation abrogates glomerular hyperfiltration occurring in the early state of diabetes mellitus. METHODS Sprague-Dawley rats were subjected to bilateral renal denervation before inducti...

background: contrast nephropathy will increase mortality up to 30% following angiographic procedures. adenosine is a crucial mediator of contrast-induced nephropathy. the purpose of this study was to investigate whether the adenosine antagonist theophylline reduces the incidence of cn after coronary angiography. methods: in this randomized, double-blind, placebo-controlled clinical trial study,...

OBJECTIVE The objective of our study was to investigate whether dynamic contrast-enhanced MRI (DCE-MRI) can detect differences and potential adaption in single-kidney parenchymal volume, blood flow, glomerular filtration rate (GFR), and filtration fraction in the remaining kidney of healthy donors compared with nondonors. Further, we evaluated the agreement in donor GFRs measured using DCE-MRI ...

INTRODUCTION Apelin is an adipokine secreted by the adipose tissue and by the endothelial cells in various parts of the body. Apelin is also expressed by the glomerular arteriolar rectus and glomerular capillary cells. We evaluated the relationship between the initial serum levels of apelin 13 with the trend of glomerular filtration rate (GFR) during a 1-year follow-up of patients with chronic ...

A study of glomerular filtration rate estimation by cockcroft-gault, mdrd and ckd-epi formula in comparison with dtpa renal scan – a comparative study among live related kidney donors in south india. a b c Original Article BACKGROUND: Renal function assessment is the most important part of donor evaluation. The Glomerular Filtration Rate (GFR) is considered to be optimal test for overall assess...

Acute renal failure (ARF) is defined as an abrupt decline in the glomerular filtration rate (GFR), as evidenced by rising serum levels of urea nitrogen and creatinine. Acute tubular necrosis (ATN) is the most common cause of ARF. ATN is an acute decline in glomerular filtration as a result of damage to the tubules in the kidney. Sepsis is the most common aetiology of ATN, causing ARF in 20–25% ...

S INCE the work of Starr [7] who concluded that the increase in venous pressure observed in congestive heart failure is due to an increased plasma volume, the “forward” theory of heart failure has been the subject of much research attempting to describe the precise mechanisms by which the extracellular volume is expanded during cardiac decompensation. Warren and Stead [Z] emphasized the diminis...

OBJECTIVES To examine the feasibility and accuracy of glomerular filtration rate (GFR) measurements in infants with sickle cell anemia (SCA). STUDY DESIGN The NHLBI/NICHD-sponsored Phase III randomized double-blinded placebo-controlled trial (BABY HUG) tests the hypothesis that hydroxyurea can prevent chronic organ damage in SCA. GFR elevation is a coprimary endpoint, measured quantitatively ...