The globulin content of the standard solution in the vials is standardized either by a Kjeldahl or a biuret determination. When available Lederle (gamma) globulin diluted 1:200 can be used for this purpose as well. The diluted Lederle standard globulin coagulates on heating and so cannot be used as a sterilized standard. An interesting phenomenon was observed while preparing the sterilized wate...

Ferritin- and fluorescein-conjugated antibody staining has been applied to a study of a mouse plasma cell tumor. The presence of myeloma globulin within cisternae of the endoplasmic reticulum was observed at a stage of the secretory process when the remainder of the cytoplasm was essentially free of labeled globulin. The distribution of ferritin suggested a functional heterogeneity among units ...

In an earlier communication (1) attention was called to the marked depressions of albumin: globulin ratios that frequently occur in the course of louse-borne typhus fever. Serum globulin concentrations in a number of cases were found to be higher than 5 grams per 100 ml. Because of the consistent rise in serum globulins in this disease, possibly a feature of the immune response, it was of inter...

To identify the genetic causality of migraine and acute, severe melalgia, we performed a linkage analysis and exome sequencing in a family with four affected individuals. We identified a variant (R21L) in exon 2 of the GC globulin gene, which is involved in the transportation of vitamin D metabolites and acts as a chemotaxic factor; this variant was co-segregated within the family. To investiga...

ELEVATION of the y-globulin concentration in cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) and other neurologic disorders has been reported (1-3). Expression of the y-globulin values in milligrams per hundred milliliters does not reveal whether this increase is due to a general elevation of total protein or y-globuin alone. Determinations of both y-globulin and total protei...

In the preceding paper (1)) the isolation, amino acid sequence, and carbohydrate composition of several glycopeptides obtained from rabbit y-globulin were described. In this communication we report the isolation and some properties of glycopeptides from a bovine y-globulin of colostrum and a human Fraction II-3 y-globulin. The amino acid sequence of a glycopeptide from bovine y-globulin has bee...

Aleutian disease-affected mink, which are markedly hypergammaglobulinemic, show a decreased half-life of the serum gamma globulin indicating that the hyperglobulinemia is due to increased production. No evidence that the gamma globulin was antibody to the infectious agent, to autologous or isologous tissues, or to antigens the animal was responding to prior to development of the disease was obt...

Many sera from normal individuals as well as patients with various disease states contain agglutinating antibodies which show specificity for antigenic determinants of gamma-globulin revealed by pepsin digestion at pH 4.1. Sera containing such agglutinating activity as well as sera negative for these agglutinators contain low molecular weight (3S-5S) components of slow gamma-mobility which inhi...

BACKGROUND Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a common inflammatory neuropathy that can be progressive, stepwise progressive, or relapsing and remitting. OBJECTIVES To further evaluate the long-term safety and tolerability of immune globulin intravenous, 10% caprylate-chromatography purified immune globulin intravenous in CIDP. DESIGN Randomized multicenter ...