نتایج جستجو برای: gist

تعداد نتایج: 3929  

2009
Mark L. Howe Marina C. Wimmer Nadine Gagnon Shannon Plumpton

The effects of associative strength and gist relations on rates of children’s and adults’ true and false memories were examined in three experiments. Children aged 5–11 and university-aged adults participated in a standard Deese/Roediger–McDermott false memory task using DRM and category lists in two experiments and in the third, children memorized lists that differed in associative strength an...

2016
Kohei Yamashita Yoshifumi Baba Junji Kurashige Masaaki Iwatsuki Katsunori Imai Daisuke Hashimoto Yasuo Sakamoto Akira Chikamoto Naoya Yoshida Toru Beppu Hideo Baba

Gastrointestinal stromal tumors (GISTs) are potentially malignant mesenchymal tumors that can give rise to distant metastases, mainly in the liver. The co-occurrence of synchronous primary liver tumors (e.g., hepatocellular carcinoma (HCC)) in patients with GIST is extremely rare. This report describes a 77-year-old male patient with liver metastasis of GIST originating in the small intestine a...

2016
Johanna Falkenhorst Susanne Grunewald Thomas Mühlenberg Adrian Marino-Enriquez Anna-Carina Reis Christopher Corless Michael Heinrich Jürgen Treckmann Lars Erik Podleska Martin Schuler Jonathan Alfred Fletcher Sebastian Bauer

Gastrointestinal stromal tumors (GIST) exhibit a strong oncogenic dependency on KIT and KIT inhibitors confer long lasting disease stabilization in the majority of patients. Nonetheless, KIT inhibition alone does not cure GIST as a subset of GIST cells evade apoptosis and eventually develop resistance. Inhibitors of Apoptosis Proteins (IAPs) may confer resistance to drug-induced apoptosis. We o...

Journal: :Updates in surgery series 2023

Tailgut cysts and rectal gastrointestinal stromal tumors (GIST) are rare found in the retrorectal space. congenital malformations resulting from incomplete regression of hindgut during embryogenesis they mostly affect women third to sixth decade life; GIST account for 5% all GIST. Both conditions may present with nonspecific symptoms such as pelvic or anal pain, bleeding weight loss. usually be...

2016

Treatment for metastatic gastrointestinal stromal tumor (GIST) is a challenge, particularly in pregnant female because of the absence of safety data concerning imatinib use during pregnancy. We report a case of metastatic GIST surgically resected during pregnancy with a favorable outcome. A treatment strategy for GIST in pregnant patients should be carefully discussed by a multidisciplinary tea...

Journal: :Molecular cancer therapeutics 2014
Mark Linch Andrew J Hayes

Tanaka and colleagues (1) present results of a novel glucose-conjugated photodynamic therapy (PDT) sensitizing agent (H2TFPC-SGlc) in gastrointestinal stromal tumor (GIST) cells (1). They state that, aside from surgery, there are currently no effective treatment strategies for GIST and demonstrate that there is selective accumulation of H2TFPC-SGlc– and PDT-induced apoptosis in GIST-T1 cells, p...

Journal: :Revista do Colégio Brasileiro de Cirurgiões 2006

2015
Mai Isosaka Takeshi Niinuma Masanori Nojima Masahiro Kai Eiichiro Yamamoto Reo Maruyama Takayuki Nobuoka Toshirou Nishida Tatsuo Kanda Takahiro Taguchi Tadashi Hasegawa Takashi Tokino Koichi Hirata Hiromu Suzuki Yasuhisa Shinomura Ramanjulu Sunkar

BACKGROUND Dysregulation of microRNA (miRNA) has been implicated in gastrointestinal stromal tumors (GISTs) but the mechanism is not fully understood. In this study, we aimed to explore the involvement of epigenetic alteration of miRNA genes in GISTs. METHODS GIST-T1 cells were treated with 5-aza-2'-deoxycytidine (5-aza-dC) and 4-phenylbutyric acid (PBA), after which miRNA expression profiles...

Journal: :Revista Española de Enfermedades Digestivas 2009

2017
Mark L. Howe Marina C. Wimmer Nadine Gagnon Shannon Plumpton

The effects of associative strength and gist relations on rates of children’s and adults’ true and false memories were examined in three experiments. Children aged 5 through 11 and universityaged adults participated in a standard Deese/Roediger-McDermott false memory task using DRM and category lists in two experiments and in the third, children memorized lists that differed in associative stre...

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