Congenital diaphragmatic hernia (CDH) may be an ideal candidate disease for in utero gene therapy as disrupted fetal lung growth plays a significant role in disease outcome. We previously demonstrated that transient in utero overexpression of CFTR during fetal development resulted in lung epithelial proliferation and differentiation. We hypothesized that gene therapy with CFTR would improve the...

transient hyperinsutinism has been implicated in the prolonged hypoglycemia observed in small for gestational age or asphyxiated newborns. tiiesc infants are at high risk for severe and permanent brain damage, thus necessitating appropriate diagnosis and correct treatment. a term male asphyxiated small for gestation 30 day infant with long-standing hypoglycemia and intractable seizures was mana...

Accepted 9 April 2008 Published Online First 14 June 2008 ABSTRACT Background: Some controversy exists over the possibility that exercise during pregnancy might increase the risk of preterm delivery. Objective: This study aimed to determine the possible cause–effect relationship between regular exercise performed during the second and third trimesters of pregnancy by previously sedentary, healt...

INTRODUCTION Intrauterine growth restriction (IUGR) is a major clinical issue for pregnant women. The purpose of this study was to evaluate color Doppler indices of the proximal and distal parts of the middle cerebral artery (MCA) of the fetus. METHODS In this cross-sectional study, 350 pregnant patients, with gestation age of 32-40 who were suspected to have intrauterine growth restriction, ...

Body-mass-index (BMI) specific recommendations to inform optimal timing of delivery are scarce. This study describes gestational age-specific risks stillbirth in women with varying pre-pregnancy BMI and assesses how these change the presence chronic hypertension (CH). was a retrospective cohort all singleton births United States, 2016-2017. Rates per 1000 total were compared by between categori...

BACKGROUND Fetal adrenal gland size is known to have a positive correlation with both gestational age and estimated body weight. In contrast, some clinical observations suggest that maturation of the adrenal stress response occurs after 30 weeks of gestation. In this study, adrenal gland size at birth in extremely preterm to term neonates was investigated using ultrasonography to evaluate the a...

uterine arteriovenous malformations (avms) are relatively rare disorders that can cause life-threatening vaginal bleeding. we describe three childbearing-age females, who had abdominal pain and heavy vaginal bleeding, and were diagnosed as uterine avm by color doppler and angiography. the patients received successful superselective transarterial embolization (tae) with n-butyl cyanoacrylate (nb...

BACKGROUND Some controversy exists over the possibility that exercise during pregnancy might increase the risk of preterm delivery. OBJECTIVE This study aimed to determine the possible cause-effect relationship between regular exercise performed during the second and third trimesters of pregnancy by previously sedentary, healthy gravidae and gestational age at the moment of delivery. METHOD...