Primary germ cell tumors of lung are extremely rare. The prognosis is usually poor, with various symptoms seriously affecting quality of life. In this paper we describe the unique case of a patient affected by an embryonal carcinoma of lung and a testicular seminoma after ten years. We also report literature about pulmonary extragonadal germ cell tumors.

background: creation of artificial gametes may provide a universal solution for these patients of lacking gametes. stem cell technology may provide a way to obtain fully functional gametes. retinoic acid (ra) can initiate meiosis. several studies have demonstrated that ra can promote sperm cells differentiation from mouse embryonic stem cells (mescs) and other cells from human embryonic stem ce...

Germ cell tumors present contrasting biological and molecular features compared to many solid tumors, which may partially explain their unusual sensitivity to chemotherapy. Reduced DNA repair capacity and enhanced induction of apoptosis appear to be key factors in the sensitivity of germ cell tumors to cisplatin. Despite substantial cure rates, some patients relapse and subsequently die of thei...

BACKGROUND AND PURPOSE Suprasellar papillary craniopharyngiomas and germ cell tumors in adults share some clinical and imaging similarities but have different therapeutic strategies and outcomes. This study aimed to evaluate the pretreatment diagnosis of these 2 tumors to improve the therapeutic outcome. MATERIALS AND METHODS We retrospectively enrolled 18 adults with papillary craniopharyngi...

Seminomas and non-seminomas are distinct categories of germ cell tumors arising from the testicles. This case report describes a rare occurrence testicular tumor exhibiting histologic characteristics seminoma in 39-year-old male patient who simultaneously has an elevated serum alpha-fetoprotein (AFP). The staging this was pT1bNxM0, stage IS. treated with right radical orchiectomy adjuvant chemo...

Neuroendocrine tumors that arise in an extragonadal teratoma are extremely rare. Somatic-type malignancy, defined as any sarcoma, carcinoma, leukemia, or lymphoma developing in a germ cell tumor, occurs in approximately 2% of all germ cell tumors. Our case represents a mediastinal mass that was incidentally found in a patient with syncope. Surgical resection confirmed mature teratoma with neuro...

background and objective: germ cell tumor (gct) accounts for approximately 2-3% of all malignancies in children. in this respect, about 20% of patients with gct are still resistant to therapy. materials and methods: the cross-sectional strategy of this survey was undertaken on 57 patients with germ cell tumor who admitted to ali asghar children hospital during the years 1990- 2003. in this stud...

3.7% of the diagnoses in the Pediatric Tumour Registry (Zentrales Tumor-Register) of the German Society for Pediatric Oncology and Haematology (Gesellschaft für Pädiatrische Onkologie und Hämatologie) concern germ cell tumors. The annual incidence has increased from 0.22 in 1980 to 0.60 per 100,000 children in 1992. The most common localizations are the coccygeal region (25%), followed by the t...

Extragonadal germ cell tumors are the rare originate commonly from mediastinum and reason is still unknown however; there theories, which suggest that gonadal cells in represent reverse migration gonads. A young female presented with mass originating middle lobe of lung right sided pleural effusion was drained, biopsy taken mass; diagnosed as choriocarcinoma. She received (BEP) Bleomycin, Etopo...