We have isolated two cDNA clones, NaPi-2 and NaPi-3, by screening rat kidney cortex and human kidney cortex cDNA libraries, respectively, for expression of sodium-dependent phosphate transport in Xenopus laevis oocytes. Substrate specificity and a detailed kinetic analysis (Na, Pi, H+ concentrations) suggested that expressed uptake activities relate to proximal tubular brush border membrane Na/...

BACKGROUND AND OBJECTIVES This study assessed whether assisted peritoneal dialysis (PD) was associated with a lower risk for technique failure using methods developed for survival analysis in the presence of competing risks. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS This retrospective cohort study, based on data from the French Language Peritoneal Dialysis Registry, analyzed 9822 incident...

* Study carried out at the Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS, Pontifical Catholic University of Rio Grande do Sul) Porto Alegre, Brazil. 1. Department of Pediatrics, Pediatric Pulmonology Sector, of the Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS, Pontifical Catholic University of Rio Grande do Sul) Hospital São Lucas Porto Alegre, Brazil 2. Pathology...

Genomic profiling is widely predicted to become a standard of care in clinical oncology, but more effective data sharing to accelerate progress in precision medicine will be required. Here, we describe cancer-associated genomic profiles from 18,004 unique adult cancers. The dataset was composed of 162 tumor subtypes including multiple rare and uncommon tumors. Comparison of alteration frequenci...

Chitosans of different molar masses were prepared by storing freshly prepared samples for up to 6 months at either 4, 25 or 40 C. The weight-average molar masses, Mw and intrinsic viscosities, [g] were then measured using size exclusion chromatography coupled to multi-angle laser light scattering (SECMALLS) and a ‘‘rolling ball” viscometer, respectively. The solution conformation of chitosan wa...

BACKGROUND There is little knowledge concerning unfavorable health conditions (UHC) associated with high level of social phobia/anxiety symptoms (SPAS) in the elderly. AIMS This cross-sectional community-based study examines five categories of UHC related to high SPAS in individuals aged 75/76 years compared with controls with lower SPAS. METHODS The study was based on data from the Oslo He...

Although organizations can gain many benefits from successful implementation of an enterprise resource planning (ERP) system, there are high failure rates in ERP implementation projects. Therefore, a better understanding of ERP implementation success is a critical. One of the best known approaches used to define and measure ERP implementation success has been the critical success factors (CSF) ...

INTRODUCTION We studied the epidemiological trends of enteric fevers (typhoid and paratyphoid fever) in Singapore from 1990 to 2009 and carried out a review of the current prevention and control measures. MATERIALS AND METHODS Epidemiological records of all reported enteric fevers maintained by the Communicable Diseases Division, Ministry of Health from 1990 to 2009 were analysed. RESULTS A...

A simple, accurate and highly sensitive method has been developed for determining the concentration of Fe in seawater. The technique applies the low-blank Mg(OH)2 coprecipitation method of Wu and Boyle [Anal. Chem. 69 (1997) 2464±2470] to preconcentrate Fe from seawater, and uses isotope dilution high-resolution ICPMS detection to ensure accuracy and enable high sensitivity. This method has bee...

BACKGROUND We report the prevalence and incidence of cardiovascular disease in older men and women in a long-term health care facility. METHODS The prevalence of hypertension, chronic atrial fibrillation, pacemaker rhythm, coronary artery disease (CAD), thromboembolic stroke, and symptomatic peripheral arterial disease (PAD) and the incidence of new coronary events, thromboembolic stroke, and...