Interpreting the results of plasma human immunodeficiency virus type 1 (HIV-1) genotypic drug-resistance tests is one of the most difficult tasks facing clinicians caring for HIV-1-infected patients. There are many drug-resistance mutations, and they arise in complex patterns that cause varying levels of drug resistance. In addition, HIV-1 exists in vivo as a virus population containing many ge...

In this case-controlled study, we tested susceptible genetic variants for Alzheimer's disease (AD) in CR1, CLU and PICALM from Genome Wide Association studies (GWAS) in southern Chinese population. 812 participants consisting of 462 late-onset Alzheimer's disease (LOAD) patients and 350 non-demented controls were recruited. We found by multivariate logistic regression analysis, that single nucl...

In this case-controlled study, we tested susceptible genetic variants for Alzheimer's disease (AD) in CR1, CLU and PICALM from genome-wide association studies (GWAS) in a southern Chinese population. Eight hundred twelve participants consisting of 462 late-onset Alzheimer's disease (LOAD) patients and 350 nondemented control subjects were recruited. We found by multivariate logistic regression ...

Genotypic data from pathogenic isolates are often used to measure the extent of infectious disease transmission. These methods include phylogenetic reconstruction and the evaluation of clustering indices. The first aim of this paper is to critique current methods used to analyse genotypic data from molecular epidemiological studies of tuberculosis. In particular, by not accounting for the mutat...

A linear model for the genotypic covariance between relatives under assortative mating comprising the "classical linear model" and the model of "selective assortative mating" is proposed. The general conditions on the genetical and developmental mechanisms of quantitative characters, as well as on selection and the mating system, on which the model is based, are explicitly stated and discussed....

BACKGROUND Growing evidence has linked HIV-1 resistance mutations and drug failure. The use of genotypic-resistance analysis to assist therapeutic decision-making in patients failing therapy has not been investigated. We assessed the virological and immunological impact of genotypic-resistance testing. METHODS We did a prospective, open, randomised, controlled study of HIV-1-infected patients...

Declines in genetic diversity within a species can affect the stability and functioning of populations. The conservation of genetic diversity is thus a priority, especially for threatened or endangered species. The importance of genetic variation, however, is dependent on the degree to which it translates into phenotypic variation for traits that affect individual performance and ecological pro...

In this study, the isolation of lactic acid bacteria was carried out from one hundred white cheese samples collected different regions Turkey. Subsequently, phenotypic and genotypic characterization isolates performed. Biochemical characteristics were determined by API 50CHL. Furthermore, biotechnological enzyme production potential screened. Genomic fingerprint profiles test detected using rep...

1. Abstract 2. Introduction 3. Materials and Methods 3.1. Study subjects 3.2. Data collection 3.3. Collection for blood specimens 3.4. Abstraction of genome DNA 3.5. Analysis of genotype 3.5.1. Determination of CYP2E1 genotypic polymorphism 3.5.2. Determination of CYP17 genotypic polymorphism 3.5.3. Determination of GSTM1 and GSTT1 genotypic polymorphism 3.6. Statistical analysis 3.7. Quality c...

tall wheat grass (agropyron elongatum), as many other grasses, benefits from wide genetic bases in iran. estimation of genetic diversity and a selection of suitable genotypes is the initial step for developing adaptable synthetic varieties in many cool season grasses. in order to investigate production, variation and genetic similarity of 25 tall wheat grass genotypes, an experiment was conduct...