1Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, Medical School, University of Brescia, Brescia, Italy; 2Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy; 3Department of Human Genetics, University of Leuven and Flanders Institute for Biotechnology, Leuven, Belgium; 4Section of Microbiolog...

M. A. Taha, S. L. Manske, E. Kristensen, J. T. Taiani, R. Krawetz, Y. Wu, S. K. Boyd, J. R. Matyas, D. E. Rancourt, and J. F. Dunn Radiology, University of Calgary, Calgary, Alberta, Canada, Kinesiology, Mechanical and Manufacturing Engineering, Medical Sciences, Departments of Oncology, Biochemistry & Molecular Biology and Medical Genetics, Radiology, Comparative Biology and Experimental Medic...

In this commentary, K. Nicole Crown and Jeff Sekelsky examine new methods for gene targeting in Drosophila. These methods, which allow for rapid replacement of large regions adjacent to existing transgenic insertions, are described in two articles published in this month’s GENETICS: “Long-Range Targeted Manipulation of the Drosophila Genome by SiteSpecific Integration and Recombinational Resolu...

1College of Information Engineering, Shanghai Maritime University, Shanghai 201306, China 2Department of Genetics and Genomics Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA 3Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China 4Department of Computer Science, Aberystwyth University, Aberystwyth, Ceredi...

Research Wavelet Methods for the Detection of Anomalies and their Application to Network Traffic Analysis D. W. Kwon1, K. Ko2, M. Vannucci3,∗,†, A. L. N. Reddy4 and S. Kim3 1Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, MD 20852, U.S.A. 2Department of Mathematics, Boise State University, ID, U.S.A. 3D...

This report documents the program and the outcomes of Dagstuhl Seminar 17252 “Computational Challenges in RNA-Based Gene Regulation: Protein-RNA Recognition, Regulation and Prediction”. Seminar June 18–21, 2017 – http://www.dagstuhl.de/17252 1998 ACM Subject Classification I.5 Pattern Recognition, I.5.1 Models, Statistical, I.5.2 Design Methodology, Feature evaluation and selection, I.5.3 Clust...

Despite advancements in genetics, chemistry, and protein engineering, recent years have seen fewer approvals of new drugs, increases in development costs, and high-profile drug withdrawals. This article focuses on technologic methods for improving drug development efficiency. These technologies include high-content cell screening, expression profiling, mass spectroscopy, mouse models of disease...

*Institute of Genetics, University of Bonn, D-53117 Bonn, Germany ‡present address: Institute of Pharmacology and Toxicology, University Hospital of Johann Wolfgang Goethe-University of Frankfurt am Main, D-60590 Frankfurt am Main, Germany §present address: Institute of Health Sciences, Sargent College, Boston University, Boston, MA 02215, USA ||Institute of Structural Biology (IBI-2), Research...

Department of Biotechnology, School of Life Sciences and Technology, University of Electronic Science and Technology of China, Chendu 610054, People’s Republic of China (Y.Z.); Department of Genetics, Cell Biology, and Development and Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota 55455 (Y.Z., X.L., J.A.B., Y.Q., C.G.S., D.F.V.); Cellectis Plant Sciences, St. Pau...

3 Scott A. Wellnitz, Daine R. Lesniak, Gregory J. Gerling and Ellen A. Lumpkin 4 5 Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030 6 Department of Systems and Information Engineering, University of Virginia, Charlottesville, 7 Virginia 22904 8 Departments of Molecular Physiology and Biophysics and of Molecular and Human Genetics, 9 Baylor College of Medicine, Housto...