Pemphigus vulgaris is a rare IgG-mediated autoimmune disease that affects the skin and mucous membranes, causing painful blistering. has been reported to be triggered or exacerbated by various factors, including genetic vulnerability, certain drugs, malignant diseases. We present case of patient who was admitted dermatology ward with complaints multiple fluid-filled lesions, initially over ches...

background: recent studies indicate an increased incidence of pertussis disease in recent years. the aim of this study was to evaluate the efficacy of the acellular vaccine for children (as a replacement of current whole cell vaccine in the expanded program on immunization) and for high-risk adults in iran through updating current best available evidence.   methods: we performed a systematic li...

Foot and Mouth Disease (FMD) control is a national regional responsibility. FMD outbreaks were detected in three farms Port-Said Governorate 2020, although animals these vaccinated with the local polyvalent inactivated vaccine. Samples from tongue epithelium vesicular fluid collected farms, where FMDV isolation was performed on BHK-21 cell culture. Viral RNA extracted virus isolates, vaccine st...

Genetic engineering is an integral approach to the development of new diagnostic techniques, drugs for human and animal diseases, foods health, tissues, cells xenotransplantation. The components vaccine disease control nutraceuticals health provide proteins; peptides other may be part life in coming days. Genetically engineered animals also offer significant environmental benefits; livestock be...

Live-attenuated retroviruses have been shown to be effective retroviral vaccines, but currently little is known regarding the mechanisms of protection. In the present studies, we used Friend virus as a model to analyze characteristics of a live-attenuated vaccine in protection against virus-induced disease. Highly susceptible mice were immunized with nonpathogenic Friend murine leukemia helper ...

Induction of high levels of broadly reactive cytotoxic T lymphocytes (CTL) remains a promising approach for an effective HIV-1 vaccine. We have developed a novel genetic-based vaccine strategy that encodes consensus overlapping peptide sets from all HIV-1 proteins scrambled together. This synthetic scrambled antigen vaccine (SAVINE) strategy has significant advantages, e.g. capacity to encode m...

Pertussis has reemerged as a major public health concern in many countries where it was once considered well controlled. Although the mechanisms responsible for continued pertussis circulation and resurgence remain elusive and contentious, many countries have nevertheless recommended booster vaccinations, the timing and number of which vary widely. Here, using a stochastic, age-stratified trans...

The central objective of this research was to test molecularly defined, live attenuated Venezuelan equine encephalitis virus (VEEV) vaccine candidates that were produced through precise genetic manipulation of rationally selected viral nucleotide sequences. Molecular clones of vaccine candidates were constructed by inserting either three independently attenuating mutations or a PE2 cleavage-sig...

Using a mouse model for genetic analysis of host resistance to virulent Mycobacterium tuberculosis, we have identified a genetic locus sst1 on mouse chromosome 1, which controls progression of pulmonary tuberculosis. In vitro, this locus had an effect on macrophage-mediated control of two intracellular bacterial pathogens, M. tuberculosis and Listeria monocytogenes. In this report, we investiga...