Numerous single nucleotide polymorphisms (SNPs) have been found in recent genome wide association studies (GWAS) to be associated with subtle plasma triglyceride (TG) variation in normolipidemic subjects. However, since these GWAS did not specifically evaluate patients with rare disorders of lipoprotein metabolism--'hyperlipoproteinemia' (HLP)--it remains largely unresolved whether any of these...

Mice infected with coxsackievirus B1 Tucson (CVB1(T)) develop chronic, post-viral myopathy (PVM) with clinical manifestations of hind limb muscle weakness and myositis. The objective of the current study was to establish the genetic basis of myopathogenicity in CVB1(T). Using a reverse genetics approach, full attenuation of PVM could only be achieved by simultaneously mutating four sites locate...

BACKGROUND AND PURPOSE Genetic determinants probably play a role in the development of intracranial aneurysms. We review the present knowledge on this issue. METHODS This work entailed a comprehensive search of the literature, a critical appraisal of the identified papers, and a personal view of limitations and future directions. RESULTS We identified 10 genome-wide linkage studies in famil...

helicobacter pylori (h. pylori) plays an important role in the development of peptic and duodenal ulcerations as well as gastric cancer. several studies have shown a strong association between specific genotypes of h. pylori and gastrointestinal tract diseases. the vaca and caga genes, which are the putative virulence factors of the bacterium, are important determinants of h. pylori-related dis...

Underpinning the global commitment to universal health coverage (UHC) is the fundamental role of health for well-being and sustainable development. UHC is proposed as an umbrella health goal in the post-2015 sustainable development agenda because it implies universal and equitable effective delivery of comprehensive health services by a strong health system, aligned with multiple sectors around...

BACKGROUND Health is a complex phenomenon and equity as a basic human right an integral part of constitutions in almost all countries in the world. In Republic of Macedonia (RM), Tuberculosis (TB) is clustered regionally and in certain ethnic groups. The main objective of this study was to analyze Social Determinants of Health (SDH) and equity in access to healthcare services for TB patients in...

Background Since the publication of the reports by the Commission on Social Determinants of Health (CSDH), many research papers have documented inequities, explaining causal pathways in order to inform policy and programmatic decision-making. At the international level, the sustainable development goals (SDGs) reflect an attempt to bring together these themes and the complexities involved in de...

Adolescent pregnancy has been typically linked to a range of adverse outcomes for mother and child. In Australia, Aboriginal and Torres Strait Islander women have a higher proportion of adolescent births compared with other adolescent Australian women, and are at greater risk of poorer psychosocial and clinical outcomes if they are not well supported during pregnancy and beyond. Drawing on exis...

Social determinants of health (SDH) are an important public health policy discourse and the concept and scope of SDH is debated within and outside of the public health field. This article concerns itself with the visibility of people with disabilities in existing SDH discourses. It employed a frequency analysis of Google and Google Scholar search hits obtained with the phrase "social determinan...