115 couples with consanguineous marriage, who had experienced reported abortions or still births either in their close relatives (3 couples) or themselves (1 couple) were exposed to genetic counseling (at the shahid akbarabadi hospital) cytogenetic studied were carried out using both conventional staining and g.t.g banding for all the cases studied. the investigation demonstrated various forms ...

conclusions il6 and il8 gene polymorphisms have no role in nash pathogenesis and liver fibrosis process, but presence of the a/a genotype in the il8 gene is associated with disease progression. patients and methods consecutive patients with biopsy proven nash and age- and gender-matched healthy individuals with normal liver function tests and normal ultrasonography were enrolled in the study. h...

background in spite of dozens of clinical trials to establish effective therapeutic and/or preventive vaccine to resolve hcv infection, no real vaccine has been proved to date. genetic vaccines based on replication-defective adenoviruses have proved to elicit strong and long lasting t-cell responses against a number of viral antigens and are even currently being used for vaccine trials in human...

the aim of this study was to analyze 22 cytokine polymorphisms in the roma population from the republic of macedonia. the roma population consists of 77 healthy unrelated individuals, residents of different geographical regions of the republic of macedonia (skopje, gostivar, and kochani). blood samples were collected after obtaining written consent. dna was isolated from peripheral blood and 22...

abstract seedless barberry (berberis vulgaris l. var. asperma) is one of the few crops that is cultured only in iran and southern parts of khorasan provinces. the origin of this variety is unknown and there has not been any study aiming to identify phylogenic relationships of this plant with other species existing in iran. in this study, aflp markers based on four primer combinations (ecori/tru...

introduction: raman spectroscopy, that is a spectroscopic technique based on inelastic scattering of monochromatic light, can provide valuable information about molecular vibrations, so using this technique we can study molecular changes in a sample. material and methods: in this research, 153 raman spectra obtained from normal and dried skin samples. baseline and electrical noise were eliminat...

how to cite this article: jafari n. neurometabolic disorders, clinical and neuroimaging finding. iran j child neurol. autumn 2014;8;4(suppl.1):23. pls see pdf.

background: familial hypertrophic cardiomyopathy (hcm) is caused by mutations in genes encoding cardiac sarcomere proteins. nowadays genetic testing of hcm plays an important role in clinical practice by contributing to the diagnosis, prognosis, and screening of high-risk individuals. the aim of this study was developing a reliable testing strategy for hcm based on linkage analysis and appropri...