In this study, attempts were made to evaluate the effect of various acrylic acid based Carbopols on the release profile of a beta-adrenoreceptor blocking drug, propranolol HCl, from matrix-type tablets invitro. For this purpose, tablets containing 160 mg of propranolol HCl along with various amounts of Carbopols 934 (C934), 971 (C971), 974 (C974) and Pemulen (Pem) were prepared using the wet gr...

The clinical application of sirolimus (SRL) as an immunosuppressive agent is largely hampered by its narrow therapeutic range. This study focused on developing SRL tablets with a sustained release profile for better safety. SRL was highly water insoluble and its solubility has been efficiently enhanced by preparing self-microemulsifying drug delivery system (SMEDDS). The SRL-SMEDDS was physical...

Aluminum plastic foamed mask package is commonly used for the packaging of tablets in the pharmaceutical companies and defective tablets can be produced during the production of the packaging. This paper studies several key algorithms of defect detection for tablets in aluminum and plastic package and designs the autodetection software which applies an image processing and recognition technolog...

In this study 50 samples of ecstasy tablets seized in Iran during the period of 2007 through 2008 were examined and their physical characteristics (appearance, marking, scored/not scored, color, weight, diameter, thickness) were determined. In order to determine the chemical characteristics of these tablets, color tests (Marquis test, Simon's test, Chen's test and Gallic acid test), Thin Layer ...

PURPOSE The aim of this study was to formulate stable film-coated montelukast sodium (MS) tablets using Opadry(®) yellow 20A82938 (Montikast(®) tablets) and to evaluate their in vitro and in vivo release profile. METHODS MS core tablets were manufactured using a direct compression method. Opadry yellow 20A82938 aqueous coating dispersion was used as the film-coating material. Dissolution of t...

AIMS To provide pharmacodynamic data of crushed and chewed ticagrelor tablets, in comparison with standard integral tablets. METHODS Ninety nine patients with stable angina were randomly assigned, in a 3:1:1 fashion, to one of the following 180mg ticagrelor loading dose (LD) formulations: A) Integral B) Crushed or C) Chewed tablets. Platelet reactivity (PR) was assessed with VerifyNow before,...

SETTING In most developing countries, paediatric tuberculosis is treated with split tablets leading to potential inaccuracy in the dose delivery and drug exposure. There is no data on the quality of first-line drugs content in split fixed-dose combination tablets. OBJECTIVE To determine Isoniazid, Pyrazinamide and Rifampicin content uniformity in split FDC tablets used in the treatment of chi...

background granisetron is a first-generation 5-ht3-receptor antagonist that has shown efficacy in preventing postoperative nausea and vomiting (ponv). in this randomized double-blind parallel-group clinical trial, we assessed the efficacy of generic granisetron versus kytril®, in the prevention of ponv in patients undergoing general anesthesia for gynaecological surgeries. method one hundred an...

objectives: the aim of this randomized clinical trial was to assess the efficacy of stimdate compared to ritalin in the treatment of children with attention deficit hyperactivity disorder (adhd). method: sixty four subjects (45 boys and 15 girls) aged 5-13 who were diagnosed with adhd based on (dsm-iv-tr) criteria were selected for this study. the subjects were randomly assigned to two groups: ...

Background:Ecstasy, mainly composed of 3,4-methylenedioxymethamphetamine (MDMA), is one of the most popular addictive synthetic drugs. This study was aimed to investigate the amount of MDMA in the ecstasy tablets seized in West Azerbaijan province, northwest Iran and also to assess the relationship between the physicochemical and morphological characteristics of the tablets. Methods: MDMA conte...