The present paper argues for a more complete integration between recent „genealogical‟ approaches to the problem of knowledge and evolutionary accounts of the development of human cognitive capacities and practices. A structural tension is pointed out between, on the one hand, the fact that the explicandum of genealogical stories is a specifically human trait and, on the other hand, the tacit a...

1 are to be congratulated on their research of the autosomal dominant Stargardt disease gene (STGD3). This study contains some extremely complex issues that require some clarification , as well as some basic and simple findings that should be emphasized. The basic issues center on gene-alogy, phenotype classification (lumping vs splitting), genotype and haplotype analysis, and statistics. Since...

Pivot relies on DeepZoom (Microsoft’s technology formerly known as SeaDragon: http://zoom.it/) to provide a smooth zooming experience. For the Silverlight PivotView experience this is done with the built-in MultiScaleImage control. Because of this, the images for a Pivot collection are stored in the Deep Zoom hierarchical tile file structure. This consists of a root-level XML file (usually with...

We present in this article a genetic type interacting particle systems algorithm and a genealogical model for estimating a class of rare events arising in physics and network analysis. We represent the distribution of a Markov process hitting a rare target in terms of a Feynman–Kac model in path space. We show how these branching particle models described in previous works can be used to estima...

Principal components analysis, PCA, is a statistical method commonly used in population genetics to identify structure in the distribution of genetic variation across geographical location and ethnic background. However, while the method is often used to inform about historical demographic processes, little is known about the relationship between fundamental demographic parameters and the proje...

Inference about population history from DNA sequence data has become increasingly popular. For human populations, questions about whether a population has been expanding and when expansion began are often the focus of attention. For viral populations, questions about the epidemiological history of a virus, e.g., HIV-1 and Hepatitis C, are often of interest. In this paper I address the following...

Acknowledgements I want to thank and acknowledge all the people who have help me with this thesis in the different ways they could help me.  Andreas Kerren, because he accepted me to develop this project.  Ilir Jusufi, to be my guide and spend his time with me helping and guiding with this project  My family, specially my parents to support me whenever I needed and helping me from Spain and ...

Evolutionary models for populations of constant size are frequently studied using the Moran model, the Wright–Fisher model, or their diffusion limits. When evolution is neutral, a random genealogy given through Kingman's coalescent is used in order to understand basic properties of such models. Here, we address the use of a genealogical perspective for models with weak frequency-dependent selec...

BACKGROUND Cardiac valvular diseases contribute to >42,000 deaths yearly in the United States, but the role of genetics in these deaths is unknown. This study evaluated the familiality of death resulting from aortic, mitral, and all valvular diseases using a population-based genealogy linked to death records. METHODS AND RESULTS The Utah Population Database contains >2 million individual reco...

OBJECTIVE To investigate the parental relationship of patients with multiple sclerosis (MS) from an extended pedigree with extensive genealogical information up to the middle of the 18th century. DESIGN Multiple sclerosis is a complex disease resulting from genetic and environmental factors. Parent-of-origin effect, a phenomenon when the same allele may express differently depending on the se...