The Gene Ontology (GO; http://www.geneontology. org) is a community-based bioinformatics resource that supplies information about gene product function using ontologies to represent biological knowledge. Here we describe improvements and expansions to several branches of the ontology, as well as updates that have allowed us to more efficiently disseminate the GO and capture feedback from the re...

Essential genes are indispensable for an organism’s living. These genes are widely discussed, and many researchers proposed prediction methods that not only find essential genes but also assist pathogens discovery and drug development. However, few studies utilized the relationship between gene functions and essential genes for essential gene prediction. In this paper, we explore the topic of e...

The Gene Ontology captures information at a very small scale, namely: molecular function, biological process, and cellular components. At this level, the Gene Ontology project should be capable of developing a semantics for every relation of genomic data to protein synthesis to the biological processes that result. In essence, the Gene Ontology should be able to describe the complete biomechani...

Gene Ontology (GO) provides a controlled vocabulary and hierarchy of terms to facilitate the annotation of gene functions and molecular attributes. Given a set of genes, a Gene Ontology Network (GON) can be constructed from the corresponding GO annotations and semantic relations among GO terms. Transitive rules can be applied to GO semantic relations to infer transitive regulations among genes....