sodium-glucose co-transporter 2 (sglt2) inhibitors are a new glucose-lowering therapy for t2dm with documented benefits on blood glucose, hypertension, weight reduction and long term cardiovascular benefit. they have an inherent osmotic diuretic effect and lead to some volume loss and possible dehydration. there is some concern about the safety of using sglt2 inhibitors in muslim type 2 diabete...

The ability of human neutrophils to express a variety of genes encoding inflammatory mediators is well documented, and mounting evidence suggests that neutrophil-derived cytokines and chemokines contribute to the recruitment of discrete leukocyte populations at inflammatory sites. Despite this, our understanding of the signaling intermediates governing the generation of inflammatory cytokines b...

Prostate cancer (PCa) has a distinct molecular signature, including characteristic chromosomal translocations, gene deletions and defective DNA damage repair mechanisms. One crucial pathway involved is homologous recombination deficiency (HRD) it found in almost 20% of metastatic castrate-resistant PCa (mCRPC). Inherited/germline mutations are associated with hereditary predisposition to early ...

Mutation or amplification in the PIK3CA gene is one of most frequent somatic mutations hormone-dependent Her2neu-negative breast cancer (HR+ Her2neu- cancer) and associated with an increased risk relapse, progression death. Understanding mechanisms leading to hyperactivation PI3K-mediated signaling cascade has led a new class drugs aimed at inhibiting/suppressing it. Studies efficacy pan-PI3K i...

Abstract Herbicides play a crucial role in maintaining crop productivity by reducing competition between weeds and crops. Protoporphyrinogen oxidase (PPO)-inhibiting herbicides trigger the photooxidative damage that destroys cell membranes. Tiafenacil is recently developed pyrimidinedione-type PPO-inhibiting herbicide has low IC 50 values plants less toxic humans compared to other PPO inhibitor...

Abstract Field and pot experiments were conducted in Greece to study the occurrence of resistance silky windgrass acetolactate synthase (ALS)- acetyl-CoA (ACCase)-inhibiting herbicides. Twenty-four populations examined whole-plant response experiments. High levels field-evolved chlorsulfuron (0% 28% control terms fresh weight reduction) with recommended field rates confirmed most populations. H...