نتایج جستجو برای: gemfibrozil
تعداد نتایج: 550 فیلتر نتایج به سال:
Background Cyclic GMP producing soluble guanylyl cyclase (sGC) is highly activated by the binding of nitric oxide (NO) messenger to its heme. Besides NO, other NO-independent molecules were shown to activate sGC. These include a class of heme-replacers (e.g., protoporphyrin IX and structurally unrelated activators BAY 58-2667 and HMR1766) or sGC stimulators (e.g., BAY 41-2272 and YC-1 and aryl-...
We report four cases of rhabdomyolysis and severe, disabling myopathy associated with HMG CoA reductase-inhibitor therapy. Patient developed symptoms following the addition of roxithromycin to combination lipid-lowering therapy with simvastatin and gemfibrozil. Patients 2 and 3 became symptomatic after developing acute on chronic renal impairment while taking simvastatin. The muscle biopsy of p...
CONTEXT In recent years, US patients have increasingly been the first to receive new medications, some of which are subsequently discovered to have suspected adverse drug reactions (SADRs). As a result, the challenge of early detection has largely shifted to the US postmarketing systems. OBJECTIVE To review the association between the use of cerivastatin sodium and the risk of rhabdomyolysis ...
Cerivastatin was recently withdrawn from the market because of 52 deaths attributed to drug-related rhabdomyolysis that lead to kidney failure. The risk was found to be higher among patients who received the full dose (0.8 mg/day) and those who received gemfibrozil concomitantly. Rhabdomyolysis was 10 times more common with cerivastatin than the other five approved statins. We address three imp...
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