We investigated the release behavior of glucagon-like peptide-1 (GLP-1) from a biodegradable injectable polymer (IP) hydrogel. This hydrogel shows temperature-responsive irreversible gelation due to the covalent bond formation through a thiol-ene reaction. In vitro sustained release of GLP-1 from an irreversible IP formulation (F(P1/D+PA40)) was observed compared with a reversible (physical gel...

Ocular drug delivery is limited both by patient acceptability and by the limited time that the dosage form is retained within the precorneal region. The timely gelation and retention of in situ-gelling ophthalmic formulations would be fundamental to improve the efficacy of drugs. The aim of this investigation was to develop ocular drug delivery system with simplicity in installation for patient...

We present a stochastic approach for the simulation of coagulation-diffusion dynamics in the gelation regime. The method couples the mass flow algorithm for coagulation processes with a stochastic variant of the diffusion-velocity method in a discretized framework. The simulation of the stochastic processes occurs according to an optimized implementation of the principle of grouping the possibl...

Abstract A DNA building block with tunable rigidity was constructed, and the corresponding hydrogel formation process investigated accordingly. high demonstrated to facilitate fast gelation. Different gelation pathways of rigid flexible blocks were revealed, a cyclized dimer intermediate proposed. The energy barrier ring-opening also shown play fundamental role in determining kinetics. Furtherm...

The structural properties of evolving random graphs are investigated. Treating linking as a dynamic aggregation process, rate equations for the distribution of node to node distances (paths) and of cycles are formulated and solved analytically. At the gelation point, the typical length of paths and cycles, l , scales with the component size k as l approximately k(1/2) . Dynamic and finite-size ...

Alginate hydrogels are commonly used in biomedical applications such as scaffolds for tissue engineering, drug delivery, and as a medium for cell immobilization. Multivalent cations are often employed to create physical crosslinks between carboxyl and hydroxyl moieties on neighbouring polysaccharide chains, creating hydrogels with a range of mechanical properties. This work describes the manufa...

A novel, high hydrolysis ratio sol-gel route for the biocompatible production of macroporous silica gels is presented. This route exploits the two step nature of the gelation reaction to remove undesired alcohol by-products from an acidic aqueous sol prior to gelation. These alcohol-free sols will gel when the pH is raised to the physiologic range in a two-step, acid/base catalyzed process. Fur...

Alginate hydrogels are commonly used in biomedical applications such as scaffolds for tissue engineering, drug delivery, and as a medium for cell immobilisation. Multivalent cations are often employed to create physical crosslinks between carboxyl and hydroxyl moieties on neighbouring polysaccharide chains, creating hydrogels with a range of mechanical properties. This work describes the manufa...