Objective: RESTOREwas a randomized, partially placebo-controlled exploratory study evaluating multiple sclerosis (MS) disease activity during a 24-week interruption of natalizumab. Methods: Eligible patients were relapse-free through the prior year on natalizumab and had no gadolinium-enhancing lesions on screening brain MRI. Patients were randomized 1:1:2 to continue natalizumab, to switch to ...

Numerous studies have established that the excretion in urine and the deposition in tissues and in cultured fibroblasts of acid mucopolysaccharides (AMPS) are markedly increased in Hurler's disease.1-8 Previous reports have indicated an increase in ganglioside content in brain and visceral organs of patients with the Hurler syndrome.9-13 The relationship of the increase in glycolipids to that o...

More than a half-billion people worldwide are infected with genital herpes [1]. During primary infection, herpes simplex virus (HSV) establishes latency in lumbosacral dorsal root ganglia. The natural history of genital herpes is characterized by frequent episodes of recurrences that may be symptomatic or asymptomatic and that transmit virus to sexual partners or from mother to infant during la...

We present TeMP—the first experimental system for testing validity of monodic temporal logic formulae. The prover implements fine-grained temporal resolution. The core operations required by the procedure are performed by an efficient resolution-based prover for classical first-order logic. 1 Monodic First-Order Temporal Logic First-Order Temporal Logic, FOTL, is an extension of classical first...

Feral plants have been known since the inception of modern agriculture, but genetic changes during what seemed to be a simple reversion domesticated form are poorly understood. Recent studies, revealing occurring in weedy rice, show an unexpected degree differentiation these feral escapes. Feralization (see Glossary) can considered, under many aspects, opposite domestication. During crop (and a...