We present numerical simulations for a possible synthesis imaging mode of the Space Interferometer Mission (SIM). We summarize the general techniques that SIM offers to perform imaging of high surface brightness sources, and discuss their strengths and weaknesses. We describe an interactive software package that is used to provide realistic, photometrically correct estimates of SIM performance ...

RV infections frequently trigger exacerbations of respiratory diseases, such as asthma, yet treatment and intervention options remain limited. Statin drugs are the treatment of choice for dyslipidemia and can also modulate immune cell function. To determine whether statin drugs modify antiviral responses of human monocytic cells, we obtained blood monocytes from donors with allergies and/or ast...

PURPOSE Nanoparticles (NPs) that target bone tissue were developed using poly(lactic-co-glycolic acid) (PLGA) copolymers and tetracycline (TC)-based bone-targeting moieties. These NPs are expected to enable the transport of drugs, such as simvastatin (SIM), for the treatment of osteoporosis. METHODS The molecular structures of TC-PLGA were validated by (1)H-NMR, and the SIM-loaded NPs were pr...

Recently, it has been more and more popular to build hybrid storage systems on the basis of SSD (Solid State Drives) and HDD (Hard Disk Drive). In order to evaluate the performance of various hybrid storage based algorithms, this paper proposes a flexible simulation tool called SH-Sim. SH-Sim aims to provide a flexible virtual hybrid disk which is made up of a virtual SSD and a virtual HDD. SH-...

Kaposi's sarcoma-associated herpesvirus (KSHV) stabilizes hypoxia-inducible factor α (HIF-1α) during latent infection, and HIF-1α reactivates lytic replication under hypoxic stress. However, the mechanism utilized by KSHV to block lytic reactivation with the accumulation of HIF-1α in latency remains unclear. Here, we report that LANA encoded by KSHV contains a unique SUMO-interacting motif (LAN...

In this paper, some results of Singh, Gopalakrishna and Kulkarni (1970s) have been extended to higher order derivatives. It has been shown that, if $sumlimits_{a}Theta(a, f)=2$ holds for a meromorphic function $f(z)$ of finite order, then for any positive integer $k,$ $T(r, f)sim T(r, f^{(k)}), rrightarrowinfty$ if $Theta(infty, f)=1$ and $T(r, f)sim (k+1)T(r, f^{(k)}), rrightarrowinfty$ if $Th...

While dealing with vague concepts often it puts us in fix to determine whether to a particular situation/case/state a particular concept applies or not. A human perceiver can determine some cases as the positive instances of the concept, and some as the negative instances of the same; but there always remain cases, which might have some similarities with some positive cases, and also have some ...

In the wave energy industry, there is a need for open source numerical codes and publicly available experimental data, both of which are being addressed through the development of WEC-Sim by Sandia National Laboratories and the National Renewable Energy Laboratory (NREL). WEC-Sim is an open source code used to model wave energy converters (WECs) when subject to incident waves. In order for the ...