spindle cell neoplasms are defined as neoplasms that consist of spindle-shaped cells in the histopathology. spindle cell neoplasms can affect the oral cavity. in the oral cavity, the origin of the spindle cell neoplasms may be traced to epithelial, mesenchymal and odontogenic components. this article aims to review the spindle cell neoplasms of the oral cavity with emphasis on histopathology.  ...

Gastric glomus tumors are rare, mesenchymal neoplasms, generally described as benign and account for nearly 1% of all gastrointestinal soft tissue tumors. The most common gastrointestinal site of involvement is the stomach, particularly the antrum. Gastric glomus tumors are submucosal tumors that lack specific clinical and endoscopic characteristics, and are often mistaken for the more common g...

INTRODUCTION Gastrointestinal stromal tumors are the most common mesenchymal neoplasms of the gastrointestinal tract. These tumors represent more than 80% of all mesenchymal tumors found in the gastrointestinal tract, though they account for only approximately 3% of all gastrointestinal malignancies. Literature offers case reports, which describe symptomatic gastrointestinal stromal tumors and ...

Gastrointestinal stromal tumours (GIST) are rare mesenchymal neoplasms in the gastrointestinal tract. The metachronous existence of GIST and gastric adenocarcinoma, though are tumours of distinct histotype, and very rare, have been reported in medical case reports in recent years. We report a case of a 74 year old man who initially presented with moderately differentiated adenocarcinoma of the ...

Methotrexate (MTX), a folic acid antagonist, is widely used in the treatment of neoplasms, psoriasis and rheumatoid arthritis. Despite its efficacy, MTX sometimes finds limited application because of its adverse effects, including renal or liver impairment, bone marrow toxicity and gastrointestinal mucosal injury. Intestinal mucositis, bleeding and peptic ulcers are well-known gastrointestinal ...

♦Corresponding Author: Saba Ebrahimian, MD Department of Surgery, Faghihi Hospital, Zand Boulevard, Shiraz, Iran Tel: 09131074391 Email: [email protected] Introduction Gastrointestinal stromal tumors (GIST) are mesenchymal neoplasms of the gastrointestinal tract that account for less than 1% of gastrointestinal (GI) tumors.1 Primary GISTs originate from all areas of the GI tract, but most comm...

Peutz-Jeghers syndrome (PJS) is an extremely rare autosomal dominant hereditary disease characterized by the growth of hamartomatous polyps in gastrointestinal tract, mucocutaneous pigmented macules and increased risk malignant neoplasms various localizations. In most cases development PJS associated with presence a mutation STK11 gene, but not all patients have this mutation. This review prese...

Gastrointestinal stromal tumours (GISTs), initially presumed to be of "true" smooth muscle origin, encompass a heterogeneous, and as yet incompletely understood, group of mesenchymal tumours with respect to their origin, cellular differentiation, and prognosis. Cellular morphology ranges from predominantly spindle shaped to epithelioid in character, whereas differentiation pathways, as determin...

Gastrointestinal involvement in plasma cell neoplasms, either as primary localizations (extramedullary plasmacytomas) or as secondary involvement in systemic multiple myeloma, is a well-known event. Accurate histological examination is crucial in defining the diagnosis. In this report, an uncommon case of duodenal localization of myeloma with plasmablastic features is described, with emphasis o...

Tumors containing both mucinous and endocrine cells (adenoendocrine tumors) can be seen in the gastrointestinal system (1). Adenoendocrine carcinomas – histologically classified first by Lewin (2) in 1987 and later by Fenoglio-Preiser (3) in 1999 are located in a wide spectrum between collision and composite tumors and are often difficult to distinguish. Composite tumors are thought to arise th...