E SUCCESS of liver therapy in Addisonian pernicious anemia and the elucidation of the role of the stomach in blood formation are milestones of modern hematology. According to Castle’s hypothesis, normal gastric juice contains a special substance, intrinsic factor, produced by the gastric mucosa. This substance reacts with an extrinsic factor contained in the food. The production is an antianemi...

The supraneural body was identified in the adult lamprey, and its secretions induced the death of a variety of tumor cells but had no effect on normal cells. The cell secretions from different lamprey tissues were separated, and these secretions killed human tumor cells to varying degrees. The cell secretions induced remarkable cell morphological alterations such as cell blebbing, and the plasm...

The effects of cadmium and bombesin on exocrine pancreatic secretions and plasma levels of gastrin and cholecystokinin (CCK) were studied in anesthetized rats with pancreatic and gastric fistulas. Rats treated only with saline were used as controls. Both control and cadmium (0.1 mg per kg) treated rats were infused with saline, secretin, and bombesin (BBS). Blood and pancreatic juice samples we...

The incidence of duodenal ulcer, especially Helicobacter pylori-negative duodenal ulcer, strongly increases with age. In humans, telomere length shortening is considered to be one critical factor in cellular senescence and organ survival. In this study, we compared basal and stimulated gastric acid and duodenal HCO(3)(-) secretory rates in aged late-generation (G(3)) telomerase-deficient (mTERC...

Understanding the fate of proteins during digestion is of especial relevance to understanding the basis of food allergies. Little is known of the immunological mechanisms involved in the sensitisation of an individual towards a food and, with the exception of the fruit and vegetable allergies (which appear to be secondary responses to tree and weed pollen allergies), it is thought that food all...

There is more or less general agreement that the calcium content of rapidly growing tumors is relatively low, whereas the potassium content is relatively high (11). Since changes in the secretions of a given parenchyma might reflect certain changes within its cells, a study of the calcium and potassium content of gastric juice from noncancerous and cancerous stomachs was undertaken, to observe ...

Since the end of the last century the standard method of assessing gastric acid secretion has been by the test meal, which was developed largely by von Leube (1876), Ewald and Boas (1885) and Rehfuss (1927). Its history and development have been reviewed by Hollander and Penner (1939) and Rovelstad (1963). The vast amounts of data collected in these original studies contributed only little to o...

Calcium balance is essential for a multitude of physiological processes, ranging from cell signaling to maintenance of bone health. Adequate intestinal absorption of calcium is a major factor for maintaining systemic calcium homeostasis. Recent observations indicate that a reduction of gastric acidity may impair effective calcium uptake through the intestine. This article reviews the physiology...