For centuries it was recognized that the stomach produces a juice, which has acidic properties, however, it was not until 1824 when Prout demonstrated the presence of hydrochloric acid in gastric juice. At the same time experiments on a patient with gastric fistula began by W. Beaumont showing alterations of acid secretion after meals and under various psychological conditions. After the discov...

Determination of normal gastric emptying time and small intestinal transit time are useful in detecting gastrointestinal motility disorders and partial obstructions of the pylorus or small intestine. This study was conducted to evaluate iodixanol as a contrast agent in the gastrointestinal tract in New Zealand White rabbit. Twelve clinically healthy adult rabbits were prepared and kept for two ...

Disorders of the upper digestive tract have a high impact on modern society, in terms of both direct and indirect health care costs and of social burden. The most common presenting symptom is either dysphagia or dyspepsia. Discriminating specific diagnoses within this wide group of diseases requires sound clinical judgment and application of procedures to distinguish organic from nonorganic dis...

Dear Editor: Recent data provide new roles for alpha-fetoprotein (AFP) in controlling the autoimmune inflammation associated with experimental autoimmune encephalomyelitis (EAE), thereby suggesting a therapeutic potential for recombinant AFP in EAE and other relative autoimmune disorders such as multiple sclerosis (MS) or rheumatoid arthritis1. Although this suggestion might be correct, it poss...

The primary clinical sign associated with gastric dysfunction is vomiting. Vomiting may also be associated with diseases of other parts of the gastrointestinal tract, or other abdominal organs. Within the gastrointestinal tract vomiting may occur due to inflammation, infection, obstruction, motility disorders, or neoplasia affecting the stomach, small intestine, or less commonly colon. Other di...

The pathophysiology of esophageal and gastric disorders is complicated and broad and includes iatrogenic, structural, inflammatory, neuromuscular, neoplastic, and infectious causes. Symptoms can be nonspecific and are often initially attributed to cardiac or respiratory causes. These disorders have both acute and chronic presentations that require different approaches to diagnosis and managemen...

Determination of normal gastric emptying time and small intestinal transit time are useful in detecting gastrointestinal motility disorders and partial obstructions of the pylorus or small intestine. This study was conducted to evaluate iodixanol as a contrast agent in the gastrointestinal tract in New Zealand White rabbit. Twelve clinically healthy adult rabbits were prepared and kept for two ...

BACKGROUND Proton pump inhibitors (PPIs) are widely applied for acid related disorders, and possess pleiotropic biological functions. The effect of PPIs on the gastric mucosa, neutrophil and Helicobacter pylori (H. pylori) infiltration and glandular atrophy has not been well investigated, particularly the duration of the effects of PPIs. OBJECTIVES To investigate the effects of PPIs on neutro...

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