Vagotomy, combined with a drainage procedure, has become increasingly popular in the surgical treatment of chronic duodenal ulcer. After operation the nervous phase of gastric secretion is abolished and the maximum secretory response to histamine, varying in degree from 70% (Falconer, 1959) to 80 %, (Gillespie, Clark, Kay, and Tankel, 1960) is reduced. The role of the vagus nerves in gastric se...

Patients with duodenal ulcer disease received either a two hour pentagastrin infusion test or a similar test with the addition of a bolus of cimetidine, 200 mg, after one hour of pentagastrin. Pentagastrin induced secretion of acid and histamine, the secretion patterns of the two being similar. Total histamine output in the gastric aspirate in the first hour of pentagastrin infusion was related...

Luminal amino acids and lack of luminal acidity as a result of acid neutralization by intragastric foodstuffs are powerful signals for acid secretion. Although the hormonal and neural pathways underlying this regulatory mechanism are well understood, the nature of the gastric luminal pH sensor has been enigmatic. In clinical studies, high pH, tryptic peptides, and luminal divalent metals (Ca(2+...