The cGMP phosphodiesterase (PDE6) involved in visual transduction in photoreceptor cells contains two inhibitory γ-subunits (Pγ) which bind to the catalytic core (Pαβ) to inhibit catalysis and stimulate cGMP binding to the GAF domains of Pαβ. During visual excitation, interaction of activated transducin with Pγ relieves inhibition. Pγ also participates in a complex with RGS9-1 and other protein...

OBJECTIVE This study assessed the impact of a psychosocial skills training program, consisting of psychoeducation, interpersonal group therapy and family education incorporated into social skills training, as an integrative approach on social functioning and quality of life of patients with schizophrenia, in comparison to standard care for an 8-month period. METHOD Thirty patients with DSM-IV s...

Methods 928 patients, aged 18–60, admitted to acute psychiatric wards in the Nordic countries were interviewed focusing on their experiences during admission. We used a questionnaire where both the MacArthurPerceived Coercion Scale (MPCS) and "The Coercion Ladder" (CL; a ten step visual analogue scale) were included. Information from medical records was obtained and participants were assessed b...

Main outcome measures Scores on the Achenbach Child Behavior Checklist (CBCL), the Center for Epidemiological StudiesDepression Scale (CES-D), the Hamilton Depression Rating Scale (HAM-D), the Schedule for Affective Disorder and Schizophrenia for School-Age Children, Epidemiological Version (K-SADS-E), and the Global Assessment of Functioning Scale (GAF); and risk of incident major depressive e...

objectives: the relationship between suicidal attempt and opioid use disorder in patients with bipolar disorder (bd) is unknown. this study aimed at shedding some light on this issue. method:178 inpatients aged 18-65 with bd type i with or without opioid use disorders were face-to-face interviewed through the persian structured clinical interview for dsm-iv axis i disorders (scid-i), the global...

Tuberculosis (TB) has long been recognized as a significant health concern worldwide. Recent advancements in noninvasive wearable devices and machine learning (ML) techniques have enabled rapid cost-effective testing for the real-time detection of TB. However, small datasets are often encountered biomedical chemical engineering domains, which can hinder success ML models result overfitting issu...

Aim In Japan, day hospitals are a method of rehabilitation for psychiatric disorders, especially recovering social functioning. Currently, 60% hospital users have schizophrenia, the majority whom long-term (for over 1 year). However, they show no progress in community participation. This study aimed to investigate whether people with schizophrenia who use can improve their functioning and recov...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background : schizophrenia requires a large share of medical resources due to its early onset and chronic and severe nature. compliance therapy is a therapy specifically designed to improve concordance with treatment for those with major mental illnesses. the aim of present study was to determine whether compliance therapy...

OBJECTIVE Recently, quality of life is a concern of health in psychiatry. Schizophrenia is a disorder that has the most regressive effects in societies' and patients' behavioural, occupational and psychiatric aspects. The main purpose of this study was to evaluate the quality of life and global function of schizophrenia patients. METHODS A hundred schizophrenia patients (with DSM-IV-TR) who h...