Radioresistance is the predominant cause for radiotherapy failure and disease progression, resulting in increased breast cancer‑associated mortality. Using gene expression signature analysis of Library Integrated Network‑Based Cellular Signatures (LINCS) Gene Expression Omnibus (GEO), aim present study was to systematically identify potential candidate radiosensitizers from known drugs. The sim...

PurposeCancer stem cells constitute an endless reserve for the maintenance and progression of tumors, they could be reason conventional therapy failure. New therapeutic strategies are necessary to specifically target them. In this context, microsecond pulsed electric fields have been selected expose D283Med cells, a human medulloblastoma cell line resulted rich in cancer normal astrocytes.Metho...