introduction: this study was performed to analyze chromosomal aletrations in g1 and g2 immortalizedmolt-4 cell line following treatment with methotrexate (mtx) and cytarabine (ara-c) alone or incombination. material and methods: molt-4 cells were cultured and manitained in rpmi-1640 supplementedwith fetal calf serum, antibiotics and l-gluthamine. cells were treated with ara-c and mtx with aconc...

The purpose of the study is to evaluate possibility preserving genetic memory original architectonics Adygeans gene pool by studying modern pools ten clan groups. Materials and methods. Ten tribal populations as well Ubykhs (total N=616) were studied a unified informative panel SNP-markers Y-chromosome (59 SNP 17 STR). Genetic portraits each population created, their position in multidimensiona...

Neuroendocrine tumors (NETs) are relatively rare and heterogeneous, mostly asymptomatic discovered incidentally. PET-CT is one of the gold diagnostic standards typically detects well-differentiated NETs using 68Gallium-Dotatate (Ga-PET/CT) more aggressive undifferentiated 18F-FDG (FDG-PET/CT). However, some displaying atypical high-grade features being detected on FDG-PET/CT. In this study, we ...

The effects of selenium on three mammary epithelial cell lines (YN-4, WAZ-2t, and CL-S1) grown in vitro were examined by immunocytochemical and transmission electron microscopy technique. The primary effect of selenium at the ultrastructural level was the appearance of electron-dense inclusions within the mitochondrial matrix. The mitochondrial inclusions were seen in all three cell lines, alth...

By combining single-channel and whole-cell patch-clamp recordings, we have established the sensitivity to omega-agatoxin IVA and omega-conotoxin MVIIC (SNX-230) of G1, G2, and G3, the three novel non-L-, non-N-type Ca2+ channels characterized previously in rat cerebellar granule cells. G1 channels were blocked irreversibly by both omega-conotoxin MVIIC and low doses of omega-agatoxin IVA (satur...

The error-free DNA damage tolerance (DDT) pathway is crucial for replication completion and genome integrity. Mechanistically, this process is driven by a switch of templates accompanied by sister chromatid junction (SCJ) formation. Here, we asked if DDT intermediate processing is temporarily regulated, and what impact such regulation may have on genome stability. We find that persistent DDT re...

In preparation to the experimental results which will be available in the future, we consider geo-neutrino production in greater detail than in [F. Mantovani et al., arXiv:hep-ph/0309013], putting the basis for a more refined model. We study geo-neutrino production for different models of matter circulation and composition in the mantle. By using global mass balance for the Bulk Silicate Earth,...

this study investigated the inhibitory effects of bacillus licheniformis on g1 and g2 aflatoxins in culture media and kilka fish meal. two concentrations of aflatoxins (8 and 12 ppb for g1 and g2) and (2 and 4 ml from aflatoxins standard per 50g of fish meal) were used in culture media and kilka fish meal respectively. the doses of bacillus were 3 and 4% for this experiment. changes of aflatoxi...

Introduction: The search for the former existence in the Early Solar System of the now extinct radionuclide Cl (T1⁄2 = 3x10 a) has proven to be difficult [e.g., 1]. This is at least partly due to the volatility of chlorine and the fact that in primitive meteorites Cl occurs in high abundance only in alteration phases such as sodalite (Na8Al6Si6O24Cl2). 36-Cl decays to both Ar by β decay (98.1 %...

A 2015 experiment by Hanson and Delft colleagues provided further confirmation that the quantum world violates Bell inequalities, being first test to close two known experimental loopholes simultaneously. The was also taken provide new evidence of 'spooky action at a distance'. Here we argue for caution about latter claim. relies on entanglement swapping, our main claim is this geometry introdu...