نتایج جستجو برای: g protein coupled receptor
تعداد نتایج: 2131208 فیلتر نتایج به سال:
Biochemical and genetic methods utilizing G protein-coupled receptor fragments have been used successfully to identify G protein-coupled receptor-interacting proteins. As noted earlier, these methods may be unable to detect interactions that require certain conformations of the native receptor protein, but have nevertheless proven quite useful in expanding our understanding of receptor regulati...
the cannabinoidergic system acquired a reputation as the most abundant g-protein coupled receptor in the cns that acts as retrograde modulator of neurotransmitter release. recently, endocannabinoids (ecbs) have been highlighted as neurodevelopmental signaling cues that exert a regulatory role in brain development. the interruption in ecb system elements (including receptors and enzymes of synth...
G protein-coupled receptor (GPCR) kinases (GRKs) phosphorylate activated heptahelical receptors, leading to their uncoupling from G proteins. Here we report six crystal structures of rhodopsin kinase (GRK1), revealing not only three distinct nucleotide-binding states of a GRK but also two key structural elements believed to be involved in the recognition of activated GPCRs. The first is the C-t...
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