Abstract Background The treatment, and efficacy thereof, is considered to be inadequate with specificity alleviation of Fibromyalgia its associated pain. patients suffer from chronic persistent widespread pain generalized tenderness. Transient receptor potential V1 (TRPV1), which reported as a Ca 2+ permeable ion channel that can activated by inflammation, involved in the development fibromyalg...

cAMP and cGMP are known to suppress vascular smooth muscle cell (SMC) proliferation. In this study, our aim was to delineate the molecular mechanism underlying cAMP and cGMP suppression of cell cycle transition in human SMCs. cAMP inhibits both platelet-derived growth factor-stimulated cyclin-dependent kinase (cdk) 2 and cdk4 activation through upregulation of the cdk2 inhibitor p27(Kip1) and d...

G-quadruplexes are higher-order nucleic acid structures that can form in G-rich telomeres and promoter regions of oncogenes. Telomeric quadruplex stabilization by small molecules can lead to telomere uncapping, followed by DNA damage response and senescence, as well as chromosomal fusions leading to deregulation of mitosis, followed by apoptosis and downregulation of oncogene expression. We rep...

To elucidate the pathways by which nitric oxide (NO) influences macrophage iron metabolism, the uptake, release, and intracellular distribution of iron in the murine macrophage cell line J774 has been investigated, together with transferrin receptor (TfR) expression and iron-regulatory protein (IRP1 and IRP2) activity. Stimulation of macrophages with interferon-g (IFN-g) and/or lipopolysacchari...

Proper attachment to the extracellular matrix is essential for cell survival. Detachment from the extracellular matrix results in an apoptotic process termed anoikis. Anoikis induction in MCF-10A mammary epithelial cells is due not only to loss of survival signals following integrin disengagement, but also to consequent downregulation of epidermal growth factor (EGFR) and loss of EGFR-induced s...

G protein-mediated downregulation of current through neuronal voltage-gated Ca *+ channels is well known. We now report that G protein activation by GTP-yS increases the Ba2+ conductance of high-voltage-activated Ca2+ channels of chick dorsal root ganglion (DRG) cells. This occurs with a delay of minutes during which the channels are inhibited by the activated G proteins. The Ba2+ current (I,,)...

To investigate the effects of training in normoxia vs. training in normobaric hypoxia (fraction of inspired O2 = 20.9 vs. 13.5%, respectively) on the regulation of Na+-K+-ATPase pump concentration in skeletal muscle (vastus lateralis), 9 untrained men, ranging in age from 19 to 25 yr, underwent 8 wk of cycle training. The training consisted of both prolonged and intermittent single leg exercise...

naphthalene diimide (nDi) derivatives have shown high affinity for telomeric guanine (G)‐quadruplexes and good antiproliferative activity in different human tumor experimental models. A trisubstituted compound (H‐NDI‐NMe2) has been reported to stabilize the telomeric G‐quadruplex and to cause telomere dysfunction and downregulation of telomerase expression. We further investigated its mechanism...

Extraintestinal pathogenic Escherichia coli (ExPEC) includes several serotypes that have been associated with colibacillosis in poultry, as well urinary tract infections and newborn meningitis humans. This study investigated the antimicrobial activities of ceftriaxone (AXO) cranberry pomace extracts (CRAN) alone or combination (CC) against multidrug-resistant (MDR) ExPEC from broiler. The growt...