Rimantadine, ribavirin, and 6-mercapto-9-(tetrahydro-2-furyl)purine, administered intraperitoneally every 8 h for 7 days starting minutes after virus challenge, had no effect on survival and mean survival time of BALB/c mice inoculated intracranially with dengue virus type 2. In contrast, intraperitoneal treatment with ribavirin 2',3',5'-triacetate, a lipophilic analog of ribavirin, effected si...

A catalyst system for the Stille cross-coupling reactions of aryl mesylates and tosylates is reported. Using the combination of Pd(OAc)2, XPhos, and CsF in t-BuOH an array of aryl and heteroaryl sulfonates were successfully employed in these reactions. Morever, heteroarylstannanes, such as furyl, thiophenyl, and N-methylpyrrole, which are often prone to decomposition, were efficiently coupled u...

2-(2-Furyl)-3-hydroxychromone (HL) reacts with MII ions in the formation of quadratic [Cu(L)2] (3), octahedral [M(L)2(OH2)2] (M = Co (1), Ni (2), Zn (4), Mn (5)) and seesaw [M(L)2] Sn (6), Pb (7)) complexes. Recrystallization complexes 1-3 presence pyridine lead to [M(L)2(py)2] (1a-3a) adducts. All compounds were characterized by Fourier transform infrared spectroscopy (FTIR). Complexes 1-7 ana...

yV-[4-(5-Nitro-2-furyl)-2-thiazolyl]formamide was fed to 50 female 5-week-old Swiss mice at a dose of 0.094% by weight of diet for 46 weeks, followed by 7 weeks of the control diet. Fifty-six mice received only the control diet. Thirty-three test mice survived 40 weeks or longer and had the following tumor incidences: urinary bladder, 31/33; generalized leukemia, 23/33; lung, 6/33; and 1 uterin...

In the title compound, C(20)H(13)ClO(2)S, the O atom and the phenyl group of the phenyl-sulfinyl substituent lie on opposite sides of the plane of the benzofuran fragment; the S-bound phenyl ring is nearly perpendicular to this plane [80.87 (5)°]. The phenyl ring in the 2-position is rotated out of the benzofuran plane, making a dihedral angle of 17.43 (7)°. The crystal structure features π-π i...